Evaluation of Diurnal Fluctuation in Parafoveal and Peripapillary Vascular Density Using Optical Coherence Tomography Angiography in Patients with Exfoliative Glaucoma and Primary Open-Angle Glaucoma

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dc.contributor.authorDemirtas, Atilim Armagan
dc.contributor.authorKarahan, Mine
dc.contributor.authorAva, Sedat
dc.contributor.authorCilem Han, Cagla
dc.contributor.authorKeklikci, Ugur
dc.date.accessioned2024-04-24T16:24:32Z
dc.date.available2024-04-24T16:24:32Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose To determine the diurnal variations in parafoveal and peripapillary vessel density using optical coherence tomography angiography in patients with exfoliative glaucoma, patients with primary open-angle glaucoma and healthy individuals. Materials and Methods In this prospective cross-sectional study, 36 exfoliative glaucoma patients, 34 primary open-angle glaucoma patients and 35 healthy individuals were examined. Optical coherence tomography angiography was used for examining the vessel density of peripapillary (radial peripapillary capillary) and parafoveal (superficial layer) regions. Optical coherence tomography angiography readings were obtained at 09:00, 11:00, 14:00 and 16:00 on the same day. Intraocular pressure values were assessed accordingly. The intraclass correlation coefficients were used to evaluate test-retest variability. Results Diurnal variation in intraocular pressure or vessel density values was not found in any parafoveal or peripapillary region in any of the groups at any hour of measurement. The vessel density in the temporal sector of the exfoliative glaucoma group was significantly lower than in the primary open-angle glaucoma group at all time points. (Mann-Whitney U test; 09:00,P= .015; 11:00,P= .002; 14:00,P= .040; and 16:00,P= .048, respectively). The test-retest repeatability was high and almost excellent for the parafoveal and peripapillary regions in each group (XFG range: 0.757 - 0.985, POAG range: 0.834 - 0.985, and control range: 0.708 - 0.983). Conclusions It may be important to estimate the diurnal fluctuation occurring in retinal haemodynamics in patients with exfoliative glaucoma and primary open-angle glaucoma despite the lack of any considerable variation in intraocular pressure and retinal vessel density values in one day. The study found that at any point of time, vessel density of radial peripapillary capillary in temporal region was lower in exfoliative glaucoma patients than in primary open-angle glaucoma patients having the same glaucoma severity.en_US
dc.identifier.doi10.1080/02713683.2020.1784437
dc.identifier.endpage106en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue1en_US
dc.identifier.pmid32546011
dc.identifier.scopus2-s2.0-85087638423
dc.identifier.scopusqualityQ1
dc.identifier.startpage96en_US
dc.identifier.urihttps://doi.org/10.1080/02713683.2020.1784437
dc.identifier.urihttps://hdl.handle.net/11468/16759
dc.identifier.volume46en_US
dc.identifier.wosWOS:000547675000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExfoliative Glaucomaen_US
dc.subjectPrimary Open-Angle Glaucomaen_US
dc.subjectDiurnal Parafoveal Vessel Densityen_US
dc.subjectDiurnal Peripapillary Vessel Densityen_US
dc.subjectOptical Coherence Tomography Angiographyen_US
dc.titleEvaluation of Diurnal Fluctuation in Parafoveal and Peripapillary Vascular Density Using Optical Coherence Tomography Angiography in Patients with Exfoliative Glaucoma and Primary Open-Angle Glaucomaen_US
dc.titleEvaluation of Diurnal Fluctuation in Parafoveal and Peripapillary Vascular Density Using Optical Coherence Tomography Angiography in Patients with Exfoliative Glaucoma and Primary Open-Angle Glaucoma
dc.typeArticleen_US

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