Causes of liver test abnormalities in newly diagnosed cancer patients and the investigation of etiological factors

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dc.contributor.authorUrakçı, Zuhat
dc.contributor.authorEbinç, Senar
dc.contributor.authorOruç, Zeynep
dc.contributor.authorKalkan, Ziya
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorKüçükköner, Mehmet
dc.contributor.authorIşıkdoğan, Abdurrahman
dc.date.accessioned2024-04-24T16:24:20Z
dc.date.available2024-04-24T16:24:20Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Anabilim Dalıen_US
dc.description.abstractObjectives: In this study, we aimed to investigate the causes of liver test abnormalities in newly diagnosed patients naive to anti-tumoral therapy. Method: This study included a total of 490 patients with ALT levels > 5X ULN on liver function tests at the initial presentation to our clinic. Data from 247 (50.4%) patients diagnosed with cancer (cohort A) and 243 (49.6%) patients without cancer (cohort B) were compared with regard to the etiology of liver test abnormalities and the risk factors. Results: The most common etiological factor in cohort A was presence of liver metastasis (31.2%, n = 77). In the comparison of the two groups with regard to etiological factors; the rates of liver metastasis [31.2% vs 0%, (p < 0.001)], drug-induced liver toxicity [30/4% vs 19.8%, (p = 0.007)], pancreaticobiliary pathology [21.5% vs 14%, (p = 0.03)] and chronic viral hepatitis [14.2% vs 7.4%, (p = 0.02)] were higher in the cohort A. The rate of NAFLD was higher in the cohort B [6.9% vs 42.2% (p < 0.001). Conclusion: In our study, the most common cause of liver test abnormalities was the presence of liver metastasis in cohort A and NAFLD in cohort B.en_US
dc.identifier.citationUrakçı, Z., Ebinç, S., Oruç, Z., Kalkan, Z., Kaplan, M. A., Küçüköner, M. ve diğerleri. (2024). Causes of liver test abnormalities in newly diagnosed cancer patients and the investigation of etiological factors. Postgraduate Medicine, 136(2), 162-168.
dc.identifier.doi10.1080/00325481.2024.2316571
dc.identifier.endpage162
dc.identifier.issn0032-5481
dc.identifier.issn1941-9260
dc.identifier.issue2
dc.identifier.pmid38331573
dc.identifier.scopus2-s2.0-85186435783
dc.identifier.scopusqualityQ1
dc.identifier.startpage168
dc.identifier.urihttps://doi.org/10.1080/00325481.2024.2316571
dc.identifier.urihttps://hdl.handle.net/11468/16656
dc.identifier.volume136
dc.identifier.wosWOS:001176994100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPostgraduate Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectAlanine aminotransferaseen_US
dc.subjectLiver function testsen_US
dc.subjectLiver test abnormalitiesen_US
dc.subjectLiver metastasisen_US
dc.titleCauses of liver test abnormalities in newly diagnosed cancer patients and the investigation of etiological factorsen_US
dc.titleCauses of liver test abnormalities in newly diagnosed cancer patients and the investigation of etiological factors
dc.typeArticleen_US

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