The Therapeutic Effect of Capsaicin and/or Steroids on Inflammation in an Experimental Allergic Rhinitis Model

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dc.contributor.authorOner, Fatih
dc.contributor.authorKozan, Gunay
dc.contributor.authorKara, Adem
dc.date.accessioned2024-04-24T17:18:37Z
dc.date.available2024-04-24T17:18:37Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Allergic rhinitis is a chronic upper respiratory disease characterized by inflammation of the nose due to the accumulation of inflammatory cells. We aimed to investigate the therapeutic efficacy of capsaicin and/or steroids in reducing the symptoms, proinflammatory cytokine levels, and inflammatory cell infiltrations in an animal model of allergic rhinitis. Materials and Methods: Thirty-five male Wistar rats were divided into five groups. Following injection and initial intranasal challenge with ovalbumin, rats were treated with intraperitoneal capsaicin (50 mg/kg) and/or steroid (10 mg/kg) injection for seven days. After nasal symptom scorings, all rats were sacrificed under anesthesia, and blood samples and nasal septa were collected for hematologic, biochemical, and histopathologic examinations. Results: The ovalbumin challenge increased nasal symptom scores, eosinophil and basophil counts, the serum IL-4, IL-5, IL-13 and IL33 levels, and histopathologic damage. Capsaicin and/or steroid administration attenuated the allergic rhinitis symptoms. There was a therapeutic effect of capsaicin and the combined use of capsaicin and steroids on experimentally-induced allergic rhinitis as reflected by decreases in allergic inflammation and secretion of cytokines. There was no difference between the CAPS, CAPS-STR, and STR groups in terms of allergic rhinitis symptoms. Conclusion: Parenteral administration of CAPS alone, and especially the combined use of CAPS and STR, effectively treats allergic rhinitis symptoms in a rat model of allergic rhinitis. Our results show that CAPS alone is not an effective alternative to STR but accelerates the recovery of allergic rhinitis.en_US
dc.identifier.doi10.21911/aai.245
dc.identifier.endpage198en_US
dc.identifier.issn1308-9234
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85181214149
dc.identifier.scopusqualityQ4
dc.identifier.startpage192en_US
dc.identifier.urihttps://doi.org/10.21911/aai.245
dc.identifier.urihttps://hdl.handle.net/11468/18846
dc.identifier.volume21en_US
dc.identifier.wosWOS:001117019500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTurkish Natl Soc Allergy and Clinical Immunologyen_US
dc.relation.ispartofAsthma Allergy Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllergic Rhinitisen_US
dc.subjectCapsaicinen_US
dc.subjectOvalbuminen_US
dc.subjectRaten_US
dc.subjectSteroiden_US
dc.titleThe Therapeutic Effect of Capsaicin and/or Steroids on Inflammation in an Experimental Allergic Rhinitis Modelen_US
dc.titleThe Therapeutic Effect of Capsaicin and/or Steroids on Inflammation in an Experimental Allergic Rhinitis Model
dc.typeArticleen_US

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