The Therapeutic Effect of Capsaicin and/or Steroids on Inflammation in an Experimental Allergic Rhinitis Model
dc.contributor.author | Oner, Fatih | |
dc.contributor.author | Kozan, Gunay | |
dc.contributor.author | Kara, Adem | |
dc.date.accessioned | 2024-04-24T17:18:37Z | |
dc.date.available | 2024-04-24T17:18:37Z | |
dc.date.issued | 2023 | |
dc.department | Dicle Üniversitesi | en_US |
dc.description.abstract | Objective: Allergic rhinitis is a chronic upper respiratory disease characterized by inflammation of the nose due to the accumulation of inflammatory cells. We aimed to investigate the therapeutic efficacy of capsaicin and/or steroids in reducing the symptoms, proinflammatory cytokine levels, and inflammatory cell infiltrations in an animal model of allergic rhinitis. Materials and Methods: Thirty-five male Wistar rats were divided into five groups. Following injection and initial intranasal challenge with ovalbumin, rats were treated with intraperitoneal capsaicin (50 mg/kg) and/or steroid (10 mg/kg) injection for seven days. After nasal symptom scorings, all rats were sacrificed under anesthesia, and blood samples and nasal septa were collected for hematologic, biochemical, and histopathologic examinations. Results: The ovalbumin challenge increased nasal symptom scores, eosinophil and basophil counts, the serum IL-4, IL-5, IL-13 and IL33 levels, and histopathologic damage. Capsaicin and/or steroid administration attenuated the allergic rhinitis symptoms. There was a therapeutic effect of capsaicin and the combined use of capsaicin and steroids on experimentally-induced allergic rhinitis as reflected by decreases in allergic inflammation and secretion of cytokines. There was no difference between the CAPS, CAPS-STR, and STR groups in terms of allergic rhinitis symptoms. Conclusion: Parenteral administration of CAPS alone, and especially the combined use of CAPS and STR, effectively treats allergic rhinitis symptoms in a rat model of allergic rhinitis. Our results show that CAPS alone is not an effective alternative to STR but accelerates the recovery of allergic rhinitis. | en_US |
dc.identifier.doi | 10.21911/aai.245 | |
dc.identifier.endpage | 198 | en_US |
dc.identifier.issn | 1308-9234 | |
dc.identifier.issue | 3 | en_US |
dc.identifier.scopus | 2-s2.0-85181214149 | |
dc.identifier.scopusquality | Q4 | |
dc.identifier.startpage | 192 | en_US |
dc.identifier.uri | https://doi.org/10.21911/aai.245 | |
dc.identifier.uri | https://hdl.handle.net/11468/18846 | |
dc.identifier.volume | 21 | en_US |
dc.identifier.wos | WOS:001117019500001 | |
dc.identifier.wosquality | N/A | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.language.iso | en | en_US |
dc.publisher | Turkish Natl Soc Allergy and Clinical Immunology | en_US |
dc.relation.ispartof | Asthma Allergy Immunology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Allergic Rhinitis | en_US |
dc.subject | Capsaicin | en_US |
dc.subject | Ovalbumin | en_US |
dc.subject | Rat | en_US |
dc.subject | Steroid | en_US |
dc.title | The Therapeutic Effect of Capsaicin and/or Steroids on Inflammation in an Experimental Allergic Rhinitis Model | en_US |
dc.title | The Therapeutic Effect of Capsaicin and/or Steroids on Inflammation in an Experimental Allergic Rhinitis Model | |
dc.type | Article | en_US |