The Therapeutic Effect of Capsaicin and/or Steroids on Inflammation in an Experimental Allergic Rhinitis Model
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Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Natl Soc Allergy and Clinical Immunology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Allergic rhinitis is a chronic upper respiratory disease characterized by inflammation of the nose due to the accumulation of inflammatory cells. We aimed to investigate the therapeutic efficacy of capsaicin and/or steroids in reducing the symptoms, proinflammatory cytokine levels, and inflammatory cell infiltrations in an animal model of allergic rhinitis. Materials and Methods: Thirty-five male Wistar rats were divided into five groups. Following injection and initial intranasal challenge with ovalbumin, rats were treated with intraperitoneal capsaicin (50 mg/kg) and/or steroid (10 mg/kg) injection for seven days. After nasal symptom scorings, all rats were sacrificed under anesthesia, and blood samples and nasal septa were collected for hematologic, biochemical, and histopathologic examinations. Results: The ovalbumin challenge increased nasal symptom scores, eosinophil and basophil counts, the serum IL-4, IL-5, IL-13 and IL33 levels, and histopathologic damage. Capsaicin and/or steroid administration attenuated the allergic rhinitis symptoms. There was a therapeutic effect of capsaicin and the combined use of capsaicin and steroids on experimentally-induced allergic rhinitis as reflected by decreases in allergic inflammation and secretion of cytokines. There was no difference between the CAPS, CAPS-STR, and STR groups in terms of allergic rhinitis symptoms. Conclusion: Parenteral administration of CAPS alone, and especially the combined use of CAPS and STR, effectively treats allergic rhinitis symptoms in a rat model of allergic rhinitis. Our results show that CAPS alone is not an effective alternative to STR but accelerates the recovery of allergic rhinitis.
Açıklama
Anahtar Kelimeler
Allergic Rhinitis, Capsaicin, Ovalbumin, Rat, Steroid
Kaynak
Asthma Allergy Immunology
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
21
Sayı
3
