Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion

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dc.contributor.authorBoyuk, Abdullah
dc.contributor.authorOnder, Akin
dc.contributor.authorKapan, Murat
dc.contributor.authorGumus, Metehan
dc.contributor.authorFirat, Ugur
dc.contributor.authorBasarali, Mustafa Kemal
dc.contributor.authorAlp, Harun
dc.date.accessioned2024-04-24T17:24:13Z
dc.date.available2024-04-24T17:24:13Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches. Materials and Methods: Forty rats were divided into four groups as control, control + EA, I/R, and I/R + EA. The control and control + EA groups were also anesthetized and subjected to laparotomy, but without clamp application. The control + EA and I/R + EA groups were given EA (85 mg/kg) orally prior to experiment. The I/R and I/R + EA groups underwent 30 minutes of intestinal ischemia and 1 hour of reperfusion. In all groups, serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were determined. TAC, total oxidative status (TOS), and oxidative stress index (OSI) in lung tissue were measured. Lung tissue histopathology was also evaluated by light microscopy. Results: TAC levels were higher in control, EA, and I/R + EA groups while TOS, OSI, and MDA levels were lower in these groups compared with I/R group. Serum MDA levels were significantly higher in I/R + EA group than that of control group. Lung tissue TAC levels were lower in I/R + EA group while OSI values were higher in that groups compared with EA group. Histological tissue damage was milder in the EA treatment group than in the I/R group. Conclusion: These results suggest that EA treatment protected the rats lung tissue against intestinal I/R injury.en_US
dc.identifier.doi10.4103/0973-1296.84236
dc.identifier.endpage228en_US
dc.identifier.issn0973-1296
dc.identifier.issn0976-4062
dc.identifier.issue27en_US
dc.identifier.pmid21969793
dc.identifier.scopus2-s2.0-80052774628
dc.identifier.scopusqualityN/A
dc.identifier.startpage224en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1296.84236
dc.identifier.urihttps://hdl.handle.net/11468/19529
dc.identifier.volume7en_US
dc.identifier.wosWOS:000294613700007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofPharmacognosy Magazine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEllagic Aciden_US
dc.subjectIntestinal Ischemia Reperfusionen_US
dc.subjectMalondialdehydeen_US
dc.subjectOxidative Stress Indexen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectTotal Oxidative Statusen_US
dc.titleEllagic acid ameliorates lung injury after intestinal ischemia-reperfusionen_US
dc.titleEllagic acid ameliorates lung injury after intestinal ischemia-reperfusion
dc.typeArticleen_US

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