Deregulation of c-Src tyrosine kinase and its downstream targets in pre-eclamptic placenta

Basit Öğe Kaydı
dc.contributor.authorIrtegun, Sevgi
dc.contributor.authorAkcora-Yildiz, Dilara
dc.contributor.authorPektanc, Gulsum
dc.contributor.authorKarabulut, Cagla
dc.date.accessioned2024-04-24T17:11:45Z
dc.date.available2024-04-24T17:11:45Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractAimPre-eclampsia is a serious pregnancy disorder characterized by the new onset of hypertension and proteinuria in the second trimester of pregnancy. The determination of a key signaling regulatory mechanism involved in placental functions is critical to understanding the pathogenesis of pre-eclampsia. The aim of this study was to examine the activity of c-Src and its downstream targets, extracellular signal-regulated kinase 1/2, p38 and Jun N-terminal kinase, as well as nuclear factor (NF)-?B in placental tissues collected from women with pre-eclampsia. MethodsTen pre-eclamptic (PE) placentas and 10 control placentas were used in this study. The Western blot method was performed to evaluate the c-Src/ mitogen activated protein kinase/NF-?B signaling pathway in each group. Resultsc-Src phosphorylation at Tyr-416, used as a measure of c-Src activity, was significantly decreased in PE placentas relative to the control. Reduced c-Src activity resulted in the suppression of extracellular signal-regulated kinase 1/2 phosphorylation and a significant reduction in the phosphorylation of p38 and Jun N-terminal kinase in PE placentas. Moreover, I?B phosphorylation was significantly elevated, while NF-?B phosphorylation was suppressed in PE placentas. ConclusionsThe c-Src/MAPK/NF-?B signaling pathway may contribute to the pathogenesis of pre-eclampsia.en_US
dc.identifier.doi10.1111/jog.13350
dc.identifier.endpage1284en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue8en_US
dc.identifier.pmid28544129
dc.identifier.scopus2-s2.0-85019613977
dc.identifier.scopusqualityQ2
dc.identifier.startpage1278en_US
dc.identifier.urihttps://doi.org/10.1111/jog.13350
dc.identifier.urihttps://hdl.handle.net/11468/17703
dc.identifier.volume43en_US
dc.identifier.wosWOS:000407080600005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-Srcen_US
dc.subjectPre-Eclampsiaen_US
dc.subjectPre-Eclamptic Placentaen_US
dc.titleDeregulation of c-Src tyrosine kinase and its downstream targets in pre-eclamptic placentaen_US
dc.titleDeregulation of c-Src tyrosine kinase and its downstream targets in pre-eclamptic placenta
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu