Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN'S WORT (H. perforatum)?

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dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorYener, Ismail
dc.contributor.authorIrtegun Kandemir, Sevgi
dc.contributor.authorOzhan Kocakaya, Safak
dc.contributor.authorFirat, Mehmet
dc.contributor.authorYigitkan, Serkan
dc.contributor.authorHasimi, Nesrin
dc.date.accessioned2024-04-24T17:27:52Z
dc.date.available2024-04-24T17:27:52Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe importance of Hypericum L. species, being used in traditional medicine, in the scientific world is increasing day by day. Hypericum species are plants that have been used in the treatment of many diseases for a long time and have healing properties. In the current study, the essential oil compositions of Hypericum scabrum L. and H. ternatum Poulter collected from different localities in Turkey were determined by GC-MS/FID. In addition, their antioxidant, cytotoxic, and antimicrobial activities with their enzyme inhibitory potentials (cholinesterase, urease, tyrosinase, elastase, and collagenase) were investigated. Also, in vitro and in silico studies of the major components of the species have been carried out on the studied enzymes. It was determined that four H. scabrum samples mainly contained alpha-pinene (55.99%-62.80%) while three H. ternatum samples contained 2-methyloctane (9.45%-22.39%) and alpha-pinene (12.75%-33.08%). While H. scabrum essential oils possessed significant biological activity potential except for the antimicrobial activity, H. ternatum samples did not. All essential oil samples of H. scabrum exhibited a high cytotoxic effect (IC50 21.67 +/- 0.34 to 34.67 +/- 0 .45 mu g/mL) against colon cancer cell line (HT-29) and indicated higher acetyl-(Inhibiton% 83.30 +/- 1.90 to 93.08 +/- 1.04) and butyryl-cholinesterase (Inhibiton% 80.58 +/- 1.19 to 93.28 +/- 1.99) inhibitory activity than the standard compound, galantamine. Furthermore, all samples of H. scabrum showed high tyrosinase (Inhibiton% 69.00 +/- 1.64 to 95.25 +/- 1.42) and elastase (Inhibiton% 27.58 +/- 0.34 to 36.69 +/- 0.18) inhibitory effects. These biological activity results indicated that H. scabrum essential oil could be used in the cosmetic and pharmaceutical industries.en_US
dc.identifier.doi10.55730/1300-0527.3494
dc.identifier.endpage+en_US
dc.identifier.issn1300-0527
dc.identifier.issue6en_US
dc.identifier.pmid37621346
dc.identifier.startpage1956en_US
dc.identifier.trdizinid1146009
dc.identifier.urihttps://doi.org/10.55730/1300-0527.3494
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1146009
dc.identifier.urihttps://hdl.handle.net/11468/20232
dc.identifier.volume46en_US
dc.identifier.wosWOS:000903416200016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypericum Ternatumen_US
dc.subjectHypericum Scabrumen_US
dc.subjectEssential Oilsen_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntimicrobialen_US
dc.subjectMolecular Dockingen_US
dc.titleDetermination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN'S WORT (H. perforatum)?en_US
dc.titleDetermination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN'S WORT (H. perforatum)?
dc.typeArticleen_US

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