Comparison of microsuturing to the use of tissue adhesives in anastomosing sciatic nerve cuts in rats

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dc.contributor.authorInaloz, SS
dc.contributor.authorAk, HE
dc.contributor.authorVayla, V
dc.contributor.authorAkin, M
dc.contributor.authorAslan, A
dc.contributor.authorSari, I
dc.contributor.authorCelik, Y
dc.date.accessioned2024-04-24T15:59:36Z
dc.date.available2024-04-24T15:59:36Z
dc.date.issued1997
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate and to compare the effects of microsuturing to that of tissue adhesives (Tissee(R)) on the healing of anastomosing peripheral nerve incisions. Forty-five Wistar-Albino rats were placed in special cages and separated into three groups (n = 15). In the control group, biliteral sciatic nerves were explored but no incision was made. In the first experimental group, bilateral sciatic nerves were incised and end-to-end anastomosing was performed by microsuturing the epineurium. In the second experimental group, tissue adhesive (Tisseel(R)) was used alone in anastomosing the sciatic nerve cuts. Assessments of the healing processes were demonstrated by 1. electromyography (EMG), 2. measuring the electrical responses of the anastomosed nerves after electrical stimuli, 3. histopathological examination. Statistical analysis of the EMG findings showed that the Tisseel group was the closest in the healing process to the control group. After applying electrical stimuli to the dissected nerves, the resistance value of the Tisseel group was nearest to those of the control group. The histopathological examinations showed highly degenerative nerve bundles and prominent foreign body granuloma at the anastomosed sites of the microsutured group. The granulomatous inflammation was observed to be much less in the Tisseel group. We conclude that the healing effect of Tisseel was found to be superior to that of microsuturing as demonstrated by the findings of EMG, electrical responses of the anastomosed nerves, and histopathological examination.en_US
dc.identifier.doi10.1007/BF01105896
dc.identifier.endpage258en_US
dc.identifier.issn0344-5607
dc.identifier.issue4en_US
dc.identifier.pmid9457720
dc.identifier.scopus2-s2.0-0031459871
dc.identifier.scopusqualityQ1
dc.identifier.startpage250en_US
dc.identifier.urihttps://doi.org/10.1007/BF01105896
dc.identifier.urihttps://hdl.handle.net/11468/14168
dc.identifier.volume20en_US
dc.identifier.wosWOS:000071313400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWalter De Gruyter & Coen_US
dc.relation.ispartofNeurosurgical Review
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHistopathologyen_US
dc.subjectMicrosurgeryen_US
dc.subjectSciatic Nerveen_US
dc.subjectTisseelen_US
dc.titleComparison of microsuturing to the use of tissue adhesives in anastomosing sciatic nerve cuts in ratsen_US
dc.titleComparison of microsuturing to the use of tissue adhesives in anastomosing sciatic nerve cuts in rats
dc.typeArticleen_US

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