Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions

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dc.contributor.authorUlas, Turgay
dc.contributor.authorBuyukhatipoglu, Hakan
dc.contributor.authorDal, Mehmet S.
dc.contributor.authorKirhan, Idris
dc.contributor.authorKaya, Zekeriya
dc.contributor.authorDemir, Mehmet E.
dc.contributor.authorTursun, Irfan
dc.date.accessioned2024-04-24T17:40:00Z
dc.date.available2024-04-24T17:40:00Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Contrast induced kidney injury is an acute renal dysfunction that is secondary to the administration of radio contrast media. The purpose of this study was to evaluate the levels of urotensin-II (UT-II) and endothelin-I (ET-I) after contrast media administration in patients undergoing percutaneous coronary interventions. Materials and Methods: In this prospective cohort study, we evaluated 78 patients with coronary artery disease who were scheduled for and ultimately underwent percutaneous coronary interventions. As a contrast material, nonionic contrast media was used in various amounts (70-480 mL). Blood and urine samples were obtained to measure U-II, ET-I just before and at the twenty-fourth hour of percutaneous coronary interventions. Results: Compared to baseline, twenty-fourth hour creatinine levels were significantly increased (P < 0.001). The twenty-fourth hour serum and urine levels of both UT-II and ET-I were also significantly increased compared to baseline (P < 0.001 for all) and 24th hour serum and urine UT-II (r = 0.322, P = 0.004; r = 0.302, P = 0.007 respectively), ET-I (r = 0.511, P < 0.001; r = 0.266, P = 0.019 respectively) levels were significantly correlated with the amount of contrast media. Conclusion: Our study indicates that; increased UT-II and ET-I levels seem to be a consequence of hazardous effects of contrast media on blood vessels and the kidney.en_US
dc.identifier.endpage209en_US
dc.identifier.issn1735-1995
dc.identifier.issue3en_US
dc.identifier.pmid23930116
dc.identifier.scopus2-s2.0-84875137689
dc.identifier.scopusqualityQ2
dc.identifier.startpage205en_US
dc.identifier.urihttps://hdl.handle.net/11468/21519
dc.identifier.volume18en_US
dc.identifier.wosWOS:000317898500007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherIsfahan Univ Med Sciencesen_US
dc.relation.ispartofJournal of Research in Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectContrast Mediaen_US
dc.subjectCoronary Angiographyen_US
dc.subjectEndothelin-Ien_US
dc.subjectUrotensin-Iien_US
dc.titleUrotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventionsen_US
dc.titleUrotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions
dc.typeArticleen_US

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