Tumour necrosis factor-alpha, interleukin-10, interferon-gamma and vitamin D receptor gene polymorphisms in patients with chronic hepatitis delta

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dc.contributor.authorKaratayli, S. C.
dc.contributor.authorUlger, Z. E.
dc.contributor.authorErgul, A. A.
dc.contributor.authorKeskin, O.
dc.contributor.authorKaratayli, E.
dc.contributor.authorAlbayrak, R.
dc.contributor.authorOzkan, M.
dc.date.accessioned2024-04-24T17:11:46Z
dc.date.available2024-04-24T17:11:46Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractNo data exist to assess certain polymorphisms that have a potential effect on the immune response in patients with chronic hepatitis delta (CHD). The aim of this study was to investigate polymorphisms in 6 polymorphic sites: IL-10 -1082 (rs1800896), IL-10 -627 (rs1800872), IFN-gamma +874 (rs62559044), TNF-alpha -308 (rs1800629), vitamin D receptor (VDR) FokI (rs2228570) and VDR TaqI (rs731236). The genotypes of 67 patients with CHD and 119 patients with chronic hepatitis B (CHB) were compared. In addition, 56 individuals with resolved hepatitis B virus (HBV) infection were used as a control group for patients with CHB. Polymorphisms in TNF-alpha, IL-10, and VDR genes were analysed using polymerase chain reaction/restriction fragment length polymorphism methods. The IFN-gamma gene polymorphism was detected by allele-specific polymerase chain reaction (PCR). Patients with CDH were more likely to have advanced liver disease compared with patients with CHB (P<0.0001). IL-10 -1082 and VDR TaqI polymorphisms showed significant differences between patients with CHD and CHB. The high secretory IL-10 -1082 genotype GG was less frequent in CHD compared with patients with CHB and resolved HBV (17.7%, 37.4% and 47.1%, respectively (PCHD vs CHB and resolved HBV). The frequency of the high secretory VDR TaqI TT genotype was 86.6% in patients with CHD, 62.7% in patients with CHB and 62.5% in resolved HBV individuals (CHD vs CHB: P<0.05). None of the polymorphisms analysed had an effect on HBV persistence. IL-10 -1082 and VDR TaqI polymorphisms may contribute to the more severe liver disease associated with CHD compared with CHB.en_US
dc.identifier.doi10.1111/jvh.12139
dc.identifier.endpage304en_US
dc.identifier.issn1352-0504
dc.identifier.issn1365-2893
dc.identifier.issue4en_US
dc.identifier.pmid24597698
dc.identifier.scopus2-s2.0-84895783842
dc.identifier.scopusqualityQ2
dc.identifier.startpage297en_US
dc.identifier.urihttps://doi.org/10.1111/jvh.12139
dc.identifier.urihttps://hdl.handle.net/11468/17711
dc.identifier.volume21en_US
dc.identifier.wosWOS:000332237800009
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Viral Hepatitis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin D Receptor Geneen_US
dc.subjectCytokine Genesen_US
dc.subjectPolymorphismen_US
dc.subjectChronic Hepatitis Ben_US
dc.subjectChronic Hepatitis Deltaen_US
dc.titleTumour necrosis factor-alpha, interleukin-10, interferon-gamma and vitamin D receptor gene polymorphisms in patients with chronic hepatitis deltaen_US
dc.titleTumour necrosis factor-alpha, interleukin-10, interferon-gamma and vitamin D receptor gene polymorphisms in patients with chronic hepatitis delta
dc.typeArticleen_US

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