The frequency of osteoporosis in patients with pemphigus vulgaris on treatment

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dc.contributor.authorUcmak, Derya
dc.contributor.authorHarman, Mehmet
dc.contributor.authorUcmak, Feyzullah
dc.contributor.authorAkpolat, Veysi
dc.date.accessioned2024-04-24T17:24:12Z
dc.date.available2024-04-24T17:24:12Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Pemphigus vulgaris was almost fatal before the advent of glucocorticoids. Unfortunately, the high doses and prolonged administration of glucocorticoids, which often needed to control the disease, result in numerous adverse effects many of which are serious. Aims: To evaluate the patients with pemphigus vulgaris on treatment in respect of osteoporosis and to compare the frequency of osteoporosis in these patients with the healthy ones. Methods: The study consisted of 40 patients with pemphigus vulgaris and 34 healthy controls. Bone mineral density measurements were obtained by dual-energy X-ray absorptiometry. Blood serum, bone parameters, and biochemical hormonal measurements were examined in both groups. Results: When the bone mineral density values of patients with pemphigus vulgaris were compared with those of the control group, there was no significant difference between hip bone mineral density values, while lumbar region T and Z scores were found significantly low in the patient group (p = 0.034 and p = 0.006, respectively). Osteoporosis, osteopenia, and normal dual-energy X-ray absorptiometry rates in the patient group were found to be 32.5%, 32.5%, and 35%, respectively. These rates were found to be 18%, 23%, and 59% in control group, respectively. There were more fractures in the patient group and the difference was statistically significant (p = 0.004). Conclusion: An increase in osteoporosis frequency and secondary fracture to osteoporosis in the patients with pemphigus vulgaris was detected.en_US
dc.identifier.doi10.4103/0378-6323.107638
dc.identifier.endpage215en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.issue2en_US
dc.identifier.pmid23442460
dc.identifier.scopus2-s2.0-84875696268
dc.identifier.scopusqualityQ3
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.4103/0378-6323.107638
dc.identifier.urihttps://hdl.handle.net/11468/19521
dc.identifier.volume79en_US
dc.identifier.wosWOS:000316906600010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Dermatology Venereology & Leprology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlucocorticoidsen_US
dc.subjectOsteoporosisen_US
dc.subjectPemphigusen_US
dc.titleThe frequency of osteoporosis in patients with pemphigus vulgaris on treatmenten_US
dc.titleThe frequency of osteoporosis in patients with pemphigus vulgaris on treatment
dc.typeArticleen_US

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