Azathioprine as a neuroprotective agent in experimental traumatic spinal cord injury

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dc.contributor.authorBahadır, Sinan
dc.contributor.authorÖnal, Mehmet Bülent
dc.contributor.authorNarin, Fırat
dc.contributor.authorBaşar, İbrahim
dc.contributor.authorYigitkanlı, Kazım
dc.contributor.authorBavbek, Murad
dc.contributor.authorZiyal, Mustafa İbrahim
dc.date.accessioned2022-07-05T07:49:09Z
dc.date.available2022-07-05T07:49:09Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.descriptionWOS:000631709500009
dc.descriptionPMID: 33372253
dc.description.abstractAIM: To evaluate the protective effects of azathioprine, a macrophage-inhibiting agent, on secondary injury in spinal cord trauma. MATERIAL and METHODS: A total of 40 Wistar rats were randomly divided into 4 groups. All the animals had undergone T8-10 laminectomy. Except in group I (control), all the animals were exposed to spinal cord trauma at the T9 level. Animals in group II (trauma) received no treatment following trauma. Animals in group 3 (treatment) and group IV (vehicle) were given intraperitoneal azathioprine 4 mg/kg and saline 2 ml, respectively, 30 minutes after the trauma. Half of the animals in each group were sacrificed 24 hours after injury and specimens were used for biochemical and immunohistochemical evaluations. The rest of the animals were followed-up for 4 weeks in terms of neurological functions and were also sacrificed to perform the histopathological analysis. RESULTS: Significant decrease in apoptotic cells and improved neurological function were observed in the animals treated with azathioprine. Biological and immunohistochemical analysis also showed less oxidative stress in this group compared to those without treatment. CONCLUSION: Azathioprine, a potent macrophage-inhibiting agent, has been shown to decrease the extent of secondary injury following spinal cord trauma.en_US
dc.identifier.citationBahadır, S., Önal, M.B., Narin, F., Başar, İ., Yiğitkanlı, K., Bavbek, M. ve diğerleri. (2021). Azathioprine as a neuroprotective agent in experimental traumatic spinal cord injury. Turkish Neurosurgery, 31(2), 211-216. http://doi.org/10.5137/1019-5149.JTN.30237-20.2en_US
dc.identifier.doi10.5137/1019-5149.JTN.30237-20.2
dc.identifier.endpage216en_US
dc.identifier.issn1019-5149
dc.identifier.issue2en_US
dc.identifier.pmid33372253
dc.identifier.scopus2-s2.0-85103474349
dc.identifier.scopusqualityQ3
dc.identifier.startpage211en_US
dc.identifier.urihttp://www.turkishneurosurgery.org.tr/abstract.php?id=2453
dc.identifier.urihttps://hdl.handle.net/11468/10111
dc.identifier.volume31en_US
dc.identifier.wosWOS:000631709500009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBaşar, İbrahim
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTraumaen_US
dc.subjectSpinal cord injuryen_US
dc.subjectSecondary injuryen_US
dc.subjectAzathioprineen_US
dc.subjectRaten_US
dc.titleAzathioprine as a neuroprotective agent in experimental traumatic spinal cord injuryen_US
dc.titleAzathioprine as a neuroprotective agent in experimental traumatic spinal cord injury
dc.typeArticleen_US

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