Mean platelet volume as an indicator of disease activity in juvenile SLE

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dc.contributor.authorYavuz, Sevgi
dc.contributor.authorEce, Aydin
dc.date.accessioned2024-04-24T16:02:00Z
dc.date.available2024-04-24T16:02:00Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of the study was to assess mean platelet volume (MPV) in children with systemic lupus erythematosus (SLE) at the active and inactive stages. Twenty children with SLE and 30 age- and gender-matched controls were enrolled. Demographic data, SLE disease activity index (SLEDAI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), MPV, complement 3 (C3), complement 4 (C4), urine protein (Up), and urine creatinine (Ucr) values upon reactivation and remission phases were recorded. MPV was statistically higher in patients than in controls and significantly increased in active phase compared to inactive phase (p = 0.001). A MPV level of 8.4 fL was determined as predictive cutoff value of activation of SLE (sensitivity 75 %, specificity 90 %). MPV was positively correlated with SLEDAI (p = 0.01, r = 0.55), ESR (p = 0.01, r = 0.45), CRP (p = 0.04, r = 0.24), and Up/Ucr (p = 0.01, r = 0.45) and negatively correlated with C3 (p = 0.02, r = -0.36), albumin (p = 0.01, r = -0.63), and Hb (p = 0.01, r = -0.48). There was not any significant association between MPV and the histological classification of lupus nephritis (p = 0.65). MPV might be used as an early indicator of reactivation in children with SLE. MPV seemed to be more accurate than ESR, CRP, and C3 for monitoring the disease activity in SLE.en_US
dc.identifier.doi10.1007/s10067-014-2540-3
dc.identifier.endpage641en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue5en_US
dc.identifier.pmid24567240en_US
dc.identifier.scopus2-s2.0-84902368264en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage637en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-014-2540-3
dc.identifier.urihttps://hdl.handle.net/11468/14560
dc.identifier.volume33en_US
dc.identifier.wosWOS:000335401500007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectDisease Activityen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.titleMean platelet volume as an indicator of disease activity in juvenile SLEen_US
dc.typeArticleen_US

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