Biological affinity evaluation of Lawsonia inermis origin Lawsone compound and its radioiodinated form via in vitro methods

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dc.contributor.authorTekin, Volkan
dc.contributor.authorMuftuler, F. Zumrut Biber
dc.contributor.authorGuldu, Ozge Kozgus
dc.contributor.authorKilcar, Ayfer Yurt
dc.contributor.authorMedine, E. Ilker
dc.contributor.authorYavuz, Murat
dc.contributor.authorUnak, Perihan
dc.date.accessioned2024-04-24T16:02:16Z
dc.date.available2024-04-24T16:02:16Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractWST-1-based cytotoxicity assay of lawsone (LW) was performed on MCF7, Caco2, BJ and Keratinocyte cells and viabilities were found as over 90 % for all cells. Significant wound healing effect of LW was reported on Keratinocyte cells. Antibacterial and antifungal activities of LW were tested on seven microorganisms with three concentrations and 1,000 A mu g/disc of LW showed antibacterial effect on Bacillus subtilis. In vitro cell incorporation of radioiodinated LW (I-131-LW) was evaluated on same cells. Keratinocyte cells uptake were 5 times more. Consequently, I-131-LW was found usable for researches about especially skin diseases in addition to breast and intestinal cancer.en_US
dc.description.sponsorshipEge University Research Fund [2013 NBE 004]en_US
dc.description.sponsorshipThis study has been supported by Ege University Research Fund (contract no 2013 NBE 004). The authors thank Prof. Serhan Sakarya for his theoretical support.en_US
dc.identifier.doi10.1007/s10967-014-3435-0
dc.identifier.endpage708en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84935081600
dc.identifier.scopusqualityQ2
dc.identifier.startpage701en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-014-3435-0
dc.identifier.urihttps://hdl.handle.net/11468/14720
dc.identifier.volume303en_US
dc.identifier.wosWOS:000347294600079
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLawsonia Inermisen_US
dc.subjectLawsoneen_US
dc.subjectI-131en_US
dc.subjectCell Cultureen_US
dc.subjectWound Healingen_US
dc.subjectAntibacterial And Antifungal Activityen_US
dc.titleBiological affinity evaluation of Lawsonia inermis origin Lawsone compound and its radioiodinated form via in vitro methodsen_US
dc.titleBiological affinity evaluation of Lawsonia inermis origin Lawsone compound and its radioiodinated form via in vitro methods
dc.typeArticleen_US

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