Biological affinity evaluation of Lawsonia inermis origin Lawsone compound and its radioiodinated form via in vitro methods
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Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
WST-1-based cytotoxicity assay of lawsone (LW) was performed on MCF7, Caco2, BJ and Keratinocyte cells and viabilities were found as over 90 % for all cells. Significant wound healing effect of LW was reported on Keratinocyte cells. Antibacterial and antifungal activities of LW were tested on seven microorganisms with three concentrations and 1,000 A mu g/disc of LW showed antibacterial effect on Bacillus subtilis. In vitro cell incorporation of radioiodinated LW (I-131-LW) was evaluated on same cells. Keratinocyte cells uptake were 5 times more. Consequently, I-131-LW was found usable for researches about especially skin diseases in addition to breast and intestinal cancer.
Açıklama
Anahtar Kelimeler
Lawsonia Inermis, Lawsone, I-131, Cell Culture, Wound Healing, Antibacterial And Antifungal Activity
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
303
Sayı
1
