The effects of curcumin on the liver and remote organs after hepatic ischemia reperfusion injury formed with Pringle manoeuvre in rats

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dc.contributor.authorOguz, A.
dc.contributor.authorKapan, M.
dc.contributor.authorOnder, A.
dc.contributor.authorKilic, E.
dc.contributor.authorGumus, M.
dc.contributor.authorBasarali, M. K.
dc.contributor.authorFirat, U.
dc.date.accessioned2024-04-24T17:38:22Z
dc.date.available2024-04-24T17:38:22Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: We aimed to investigate the effects of curcumin on ischemia/reperfusion (IR) injury of the liver and distant organs resulting from liver blood flow arrest. MATERIALS AND METHODS: Totally 40 rats, divided into four groups, each included 10 rats were used. Group I as only laparatomy, Group II laparatomy and curcumin application, Group III hepatic IR; and Group IV as hepatic IR and curcumin application group. Ischemia was generated by hepatoduedonal ligament clamping for 30 minutes and then reperfusion is started. Curcumin capsules were opened and appropriate dose had been created within weighing scales. After calculations, the powder was diluted with saline. Fifteen minutes before the ischemia, curcumin was applied via oral gavage. Blood samples were taken from the animals for biochemical analysis at 60th minutes of the experiment in the first and second groups; 30 minutes after beginning reperfusion in the third and forth groups. Simultaneously, liver, lung and kidney tissues were sampled for biochemical and histopathological examinations. RESULTS: Plasma malondialdehyde levels were found to be higher (p < 0.001), but total antioxidant activity values were not different in IR group compared with IR + curcumin group (p > 0.05). Biochemical and histopathological evaluation of tissue samples revealed that there were no differences in total antioxidant activity, total oxidant activity and histopathologic scores in IR + curcumin group compared with values of IR group (p > 0.05). CONCLUSIONS: Curcumin did not reduce the effects of hepatic ischemia reperfusion injury on the liver and distant organs including kidneys and lungs significantly.en_US
dc.description.sponsorshipDicle University, Coordination of Scientific Research Projectsen_US
dc.description.sponsorshipThis study was supported by Dicle University, Coordination of Scientific Research Projects.en_US
dc.identifier.endpage466en_US
dc.identifier.issn1128-3602
dc.identifier.issue4en_US
dc.identifier.pmid23467943
dc.identifier.scopus2-s2.0-84878527645
dc.identifier.scopusqualityQ2
dc.identifier.startpage457en_US
dc.identifier.urihttps://hdl.handle.net/11468/21423
dc.identifier.volume17en_US
dc.identifier.wosWOS:000319225600005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatic Ischemia-Reperfusionen_US
dc.subjectCurcuminen_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.subjectLungen_US
dc.subjectRemote Organsen_US
dc.titleThe effects of curcumin on the liver and remote organs after hepatic ischemia reperfusion injury formed with Pringle manoeuvre in ratsen_US
dc.titleThe effects of curcumin on the liver and remote organs after hepatic ischemia reperfusion injury formed with Pringle manoeuvre in rats
dc.typeArticleen_US

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