Continuous veno-venous hemodiafiltration in neonates with maple syrup urine disease

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dc.authorid0000-0001-8093-5583en_US
dc.contributor.authorDeğer, İbrahim
dc.contributor.authorÇelik, Muhittin
dc.contributor.authorTaş, İbrahim
dc.contributor.authorSamancı, Serhat
dc.date.accessioned2022-03-10T10:59:35Z
dc.date.available2022-03-10T10:59:35Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.descriptionWOS:000760266600001
dc.descriptionPMID: 35166449
dc.description.abstractIntroduction Herein, we aimed to discuss our experience in 16 newborn patients with Maple syrup urine disease (MSUD) who were treated with urgent renal replacement therapy (RRT). Methods The patients underwent continuous veno-venous hemodiafiltration (CVVHDF) or peritoneal dialysis (PD) as renal replacement therapy. Results Eleven (68.75%) patients underwent CVVHDF and five (31.25%) underwent peritoneal dialysis. The median leucine reduction rate per hour was 2.56% (1.75-7.6) in the CVVHDF group, 0.78% (0.54-1.83) in the PD group, and was significantly higher in the CVVHDF group (p = 0.001). Posttreatment plasma leucine levels were found to be 198 (20-721) mu mol/L in the CVVHDF group and 600 (250-967) mu mol/L in the PD group, and CVVHDF was found to be significantly lower (p = 0.08). Complications such as hypotension, electrolyte imbalance, and filter obstruction occurred in the CVVHDF group. Conclusion This study showed that CVVHDF is more effective than PD for rapidly eliminating elevated leucine levels caused by MSUD in the newborn and it is not associated with increased complication rates.en_US
dc.identifier.citationDeğer, İ., Çelik, M., Taş, İ. ve Samancı, S. (2022). Continuous veno-venous hemodiafiltration in neonates with maple syrup urine disease. Therapeutic Apheresis and Dialysis, 26(3 (SI)), 658-666.en_US
dc.identifier.doi10.1111/1744-9987.13816
dc.identifier.endpage666
dc.identifier.issn1744-9979
dc.identifier.issn1744-9987
dc.identifier.issue3(SI)
dc.identifier.pmid35166449
dc.identifier.scopus2-s2.0-85125133081
dc.identifier.scopusqualityQ3
dc.identifier.startpage658
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/1744-9987.13816
dc.identifier.urihttps://hdl.handle.net/11468/9370
dc.identifier.volume26en_US
dc.identifier.wosWOS:000760266600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDeğer, İbrahim
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofTherapeutic Apheresis and Dialysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCVVHDFen_US
dc.subjectMSUDen_US
dc.subjectNewbornen_US
dc.subjectPeritoneal dialysisen_US
dc.titleContinuous veno-venous hemodiafiltration in neonates with maple syrup urine diseaseen_US
dc.titleContinuous veno-venous hemodiafiltration in neonates with maple syrup urine disease
dc.typeArticleen_US

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