Effects of caffeic acid phenethyl ester on wound healing of nasal mucosa in the rat: an experimental study

Basit Öğe Kaydı
dc.contributor.authorKinis, Vefa
dc.contributor.authorOzbay, Musa
dc.contributor.authorAkdag, Mehmet
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorGul, Aylin
dc.contributor.authorYilmaz, Beyhan
dc.contributor.authorOzkan, Hakan
dc.date.accessioned2024-04-24T16:10:47Z
dc.date.available2024-04-24T16:10:47Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: Wound healing of the nasal mucosa is a highly complex process that restores the anatomical and functional integrity of tissue that has been exposed to trauma. In this experimental study, our aim was to use histopathological examination to investigate the effects of caffeic acid phenethyl ester on the wound healing of rat nasal mucosa after mechanical trauma. Materials and methods: The rats were randomly divided into 3 experimental groups: a non-treated group (n = 7), a control saline group (n = 7) and a caffeic acid phenethyl ester group (n = 7). The non-treated group received no treatment for 15 days. The second group was administered saline (2.5 mL/kg, intraperitoneal) once a day for 15 days. The third group received caffeic acid phenethyl ester intraperitoneally at a dose of 10 mu mol/kg once a day for 15 days. At the beginning of the study, unilateral mechanical nasal trauma was induced on the right nasal mucosa of all rats in the three groups using a brushing technique. Samples were stained using hematoxylin and eosin solution and were examined by a pathologist using a light microscope. Results: The severity of inflammation was milder in the caffeic acid phenethyl ester group compared with that in the non-treated and saline groups (P < 0.05). The subepithelial thickness index was lower in the experimental group (P < 0.05). Goblet cell and ciliated cell loss was substantially reduced in the experimental group compared with the non-treated and saline groups (P <0.05). Conclusions: Caffeic acid phenethyl ester decreases inflammation and the loss of goblet cells and ciliated cells. Therefore, caffeic acid phenethyl ester has potential beneficial effects on the wound healing of nasal mucosa in the rat. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.amjoto.2014.02.008
dc.identifier.endpage486en_US
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.issue4en_US
dc.identifier.pmid24767474
dc.identifier.scopus2-s2.0-84902544344
dc.identifier.scopusqualityQ1
dc.identifier.startpage482en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2014.02.008
dc.identifier.urihttps://hdl.handle.net/11468/15106
dc.identifier.volume35en_US
dc.identifier.wosWOS:000338090900004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal of Otolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffects of caffeic acid phenethyl ester on wound healing of nasal mucosa in the rat: an experimental studyen_US
dc.titleEffects of caffeic acid phenethyl ester on wound healing of nasal mucosa in the rat: an experimental study
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu