Relationship among serum selenium levels, lipid peroxidation, and acute bronchiolitis in infancy

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dc.contributor.authorGurkan, F
dc.contributor.authorAtamer, Y
dc.contributor.authorEce, A
dc.contributor.authorKocyigit, Y
dc.contributor.authorTuzun, H
dc.contributor.authorMete, M
dc.date.accessioned2024-04-24T17:17:55Z
dc.date.available2024-04-24T17:17:55Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractThirty-four infants with acute bronchiolitis and 25 age-matched healthy controls were enrolled to investigate the possible relationship between serum malondialdehyde (MDA) and selenium (Se) levels and the occurrence and severity of acute bronchiolitis in children. Serum samples were taken for serum Se and MDA measurements, and the clinical score was assessed at admission. Blood was taken again from the children with bronchiolitis at 2 mo after discharge from the hospital. Mean serum MDA levels were significantly higher in patients with acute bronchiolitis than at the postbronchiolitis stage and the controls (4.2+/-2.5 nmol/L, 1.4+/-0.8 nmol/L, and 0.7+/-0.2 nmol/L, respectively [p<0.001]). Infants with bronchiolitis had lower mean serum Se levels at the acute stage than after 2 mo (31.7+/-28.9 mug/L versus 68.4+/-26.4 mug/L, p<0.05, respectively); both of which were significantly lower than the control group measurements (145.0+/-21.9 mug/L) (p<0.001). There was a negative correlation between serum MDA and Se levels in the patient group (r=-0.85, p<0.001). The age of the patient, child's immunization status, parental smoking habit, and family crowding index were not correlated with serum Se, MDA levels, or clinical score at admission. In conclusion, increased MDA levels and impaired Se status demonstrate the presence of possible relationship of these parameters with pathogenesis of acute bronchiolitis, and antioxidant supplementation with Se might be thought to supply a beneficial effect against bronchiolitis.en_US
dc.identifier.doi10.1385/BTER:100:2:097
dc.identifier.endpage104en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid15326359
dc.identifier.scopus2-s2.0-4444312167
dc.identifier.scopusqualityQ1
dc.identifier.startpage97en_US
dc.identifier.urihttps://doi.org/10.1385/BTER:100:2:097
dc.identifier.urihttps://hdl.handle.net/11468/18440
dc.identifier.volume100en_US
dc.identifier.wosWOS:000223448900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBronchiolitisen_US
dc.subjectWheezing Infanten_US
dc.subjectSeleniumen_US
dc.subjectAntioxidanten_US
dc.subjectLipid Peroxidationen_US
dc.subjectMalondialdehydeen_US
dc.titleRelationship among serum selenium levels, lipid peroxidation, and acute bronchiolitis in infancyen_US
dc.titleRelationship among serum selenium levels, lipid peroxidation, and acute bronchiolitis in infancy
dc.typeArticleen_US

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