The Effect of Corticosteroid Against Streptomycin Ototoxicity

Basit Öğe Kaydı
dc.contributor.authorKinis, Vefa
dc.contributor.authorOzbay, Musa
dc.contributor.authorBakir, Salih
dc.contributor.authorSengul, Engin
dc.contributor.authorYorgancilar, Ediz
dc.contributor.authorKeles, Aysenur
dc.contributor.authorAlabalik, Ulas
dc.date.accessioned2024-04-24T17:08:35Z
dc.date.available2024-04-24T17:08:35Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this experimental study was to determine the possible protective role of corticosteroid in prevention of streptomycin-induced ototoxicity. Twenty-eight adult Wistar albino rats were divided into 4 groups: control (n = 7), streptomycin (n = 7), corticosteroid (n = 7), and streptomycin + corticosteroid (n = 7). Rats were tested with distortion product otoacoustic emissions (DPOAEs) in the beginning and at the end of the study. The animals in all groups were killed under general anesthesia on the 45th day after the last DPOAE measurements. Hearing results were analyzed statistically to determine differences in amplitudes of DPOAE. In addition, the cochleas of each rat were evaluated by histopathologic and immunohistochemical examination. Significant difference was not observed in cochlear hair cells in the control and corticosteroid groups, whereas severe degeneration of hair cells and increased apoptotic cells were observed in the streptomycin group. Moderate degeneration was observed in the streptomycin + corticosteroid group. The hair cells were partially intact. DP-gram of the streptomycin and streptomycin + corticosteroid groups was significantly deteriorated (P < 0.05). The coadministration of steroids with streptomycin, which has a serious ototoxic effect, did not lead to a limitation of this harmful effect.en_US
dc.identifier.doi10.1097/SCS.0b013e3182a232a5
dc.identifier.endpage1730en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue5en_US
dc.identifier.pmid24036765
dc.identifier.scopus2-s2.0-84885037371
dc.identifier.scopusqualityQ3
dc.identifier.startpage1726en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0b013e3182a232a5
dc.identifier.urihttps://hdl.handle.net/11468/17389
dc.identifier.volume24en_US
dc.identifier.wosWOS:000330353200086
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStreptomycinen_US
dc.subjectCorticosteroiden_US
dc.subjectOtotoxicityen_US
dc.subjectHairy Cellen_US
dc.subjectOtoacoustic Emissionen_US
dc.titleThe Effect of Corticosteroid Against Streptomycin Ototoxicityen_US
dc.titleThe Effect of Corticosteroid Against Streptomycin Ototoxicity
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu