Total oxidant/antioxidant status, copper and zinc levels in acute ischemic stroke patients after mechanical thrombectomy

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dc.contributor.authorKaraaslan, Fırat
dc.contributor.authorDemir, Fidel
dc.contributor.authorYılmaz, Reşit
dc.contributor.authorAkıl, Eşref
dc.date.accessioned2023-10-23T13:16:16Z
dc.date.available2023-10-23T13:16:16Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.description.abstractBackground and purpose: We aimed to identify the relationship of total antioxidant status, total oxidant status, and copper (Cu) and zinc (Zn) situations with the short-term prognostic and stroke severity in acute ischemic stroke cases who were successfully recanalized by mechanical thrombectomy. Methods: A study of 36 acute ischemic stroke patients and 22 controls were prospectively studied. Tube samples were attained at admission and 24 h after recanalization. In patients who were successfully recanalized (thrombolysis in cerebral infarction ≥ 2b), a 3-month modified Rankin scale (mRS) score of 0–2 was considered a good prognosis, and a score of 3–6 was considered a poor prognosis. Results: Admission Cu levels were significantly higher in the poor prognosis group (p = 0.031). In the multivariate logistic regression analysis, Cu was not associated with poor prognosis (p = 0.357). Cu and Zn levels were lower in the patients group compared to controls (p = 0.014 and p = 0.010, respectively). There was no correlation between National Institute of Health Stroke Scale and biomarkers (p > 0.05). The temporal variation of biomarkers did not differ significantly between the good prognosis and poor prognosis groups (p interaction > 0.05). Conclusions: High admission Cu levels were associated with poor prognosis, but this association was limited. In addition, Cu and Zn levels were statistically lower in patients. There was no relationship between total antioxidant/oxidant status and short-term prognosis or stroke severity .en_US
dc.identifier.citationKaraaslan, F., Demir, F., Yılmaz, R. ve Akıl, E. (2023). Total oxidant/antioxidant status, copper and zinc levels in acute ischemic stroke patients after mechanical thrombectomy. Clinical Neurology and Neurosurgery, (229), 1-6.en_US
dc.identifier.doi10.1016/j.clineuro.2023.107718
dc.identifier.endpage6en_US
dc.identifier.issn0303-8467
dc.identifier.issue229en_US
dc.identifier.pmid37121029
dc.identifier.scopus2-s2.0-85153599408
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0303846723001348?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/12907
dc.identifier.wosWOS:000989180800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkıl, Eşref
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofClinical Neurology and Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute ischemic strokeen_US
dc.subjectCopperen_US
dc.subjectMechanical thrombectomyen_US
dc.subjectOxidationen_US
dc.subjectZincen_US
dc.titleTotal oxidant/antioxidant status, copper and zinc levels in acute ischemic stroke patients after mechanical thrombectomyen_US
dc.titleTotal oxidant/antioxidant status, copper and zinc levels in acute ischemic stroke patients after mechanical thrombectomy
dc.typeArticleen_US

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