Hyperbaric Oxygen Preconditioning Provides Preliminary Protection Against Doxorubicin Cardiotoxicity

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dc.contributor.authorTezcan, Orhan
dc.contributor.authorKarahan, Oguz
dc.contributor.authorAlan, Mustafa
dc.contributor.authorEkinci, Cenap
dc.contributor.authorYavuz, Celal
dc.contributor.authorDemirtas, Sinan
dc.contributor.authorEkinci, Aysun
dc.date.accessioned2024-04-24T17:28:13Z
dc.date.available2024-04-24T17:28:13Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Doxorubicin (DOX) is generally recognized to have important cardiotoxic side effects. Studies are contradictory about the interaction between hyperbaric oxygen (HBO2) therapy and doxorubicin-induced cardiomyotoxicity. Recent data suggests that HBO2 therapy can lead to preconditioning of myocardium while generating oxidative stress. Herein we have investigated the effect of HBO2 therapy in a DOX-induced cardiomyocyte injury animal model. Methods: Twenty-one rats were divided into three equal groups as follows: 1) Group 1 is a control group (without any intervention), used for evaluating the basal cardiac structures and determining the normal value of cardiacs and serum oxidative markers; 2) Group 2 is the doxorubicin group (single dose i.p. 20 mg/kg doxorubicin) for detecting the cardiotoxic and systemic effects of doxorubicin; 3) Group 3 is the doxorubicin and HBO2 group (100% oxygen at 2.5 atmospheric for 90 minutes, daily), for evaluating the effect of HBO2 in doxorubicin induced cardiotoxicity. At the end of the protocols, the hearts were harvested and blood samples (2 ml) were obtained. Results: The doxorubicin treated animals (Group 2) had increased oxidative stress markers (both cardiac and serum) and severe cardiac injury as compared to the basal findings in the control group. Nevertheless, the highest cardiac oxidative stress index was detected in Group 3 (control vs. Group 3, p = 0.01). However, histological examination revealed that cardiac structures were well preserved in Group 3 when compared with Group 2. Conclusions: Our results suggest that HBO2 preconditioning appears to be protective in the doxorubicin-induced cardiotoxicity model. Future studies are required to better elucidate the basis of this preconditioning effect of HBO2.en_US
dc.identifier.doi10.6515/ACS20160404B
dc.identifier.endpage155en_US
dc.identifier.issn1011-6842
dc.identifier.issue2en_US
dc.identifier.pmid28344418
dc.identifier.scopus2-s2.0-85015700364
dc.identifier.scopusqualityQ3
dc.identifier.startpage150en_US
dc.identifier.urihttps://doi.org/10.6515/ACS20160404B
dc.identifier.urihttps://hdl.handle.net/11468/20370
dc.identifier.volume33en_US
dc.identifier.wosWOS:000396964400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaiwan Soc Cardiologyen_US
dc.relation.ispartofActa Cardiologica Sinica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular Toxicityen_US
dc.subjectDoxorubicinen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectOxidative Stressen_US
dc.titleHyperbaric Oxygen Preconditioning Provides Preliminary Protection Against Doxorubicin Cardiotoxicityen_US
dc.titleHyperbaric Oxygen Preconditioning Provides Preliminary Protection Against Doxorubicin Cardiotoxicity
dc.typeArticleen_US

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