Identification of Phenolic Compounds by LC-MS/MS and Evaluation of Bioactive Properties of Two Edible Halophytes: Limonium effusum and L. sinuatum

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dc.contributor.authorBaysal, Ipek
dc.contributor.authorEkizoglu, Melike
dc.contributor.authorErtas, Abdulselam
dc.contributor.authorTemiz, Burak
dc.contributor.authorAgalar, Hale Gamze
dc.contributor.authorYabanoglu-Ciftci, Samiye
dc.contributor.authorTemel, Hamdi
dc.date.accessioned2024-04-24T17:20:52Z
dc.date.available2024-04-24T17:20:52Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis work aimed to evaluate the phenolic content and in vitro antioxidant, antimicrobial and enzyme inhibitory activities of the methanol extracts and their fractions of two edible halophytic Limonium species, L. effusum (LE) and L. sinuatum (LS). The total phenolic content resulted about two-fold higher in the ethyl acetate fraction of LE (522.82 +/- 5.67 mg GAE/g extract) than in that of LS (274.87 +/- 1.87 mg GAE/g extract). LC-MS/MS analysis indicated that tannic acid was the most abundant phenolic acid in both species (71,439.56 +/- 3643.3 mu g/g extract in LE and 105,453.5 +/- 5328.1 mu g/g extract in LS), whereas hyperoside was the most abundant flavonoid (14,006.90 +/- 686.1 mu g/g extract in LE and 1708.51 +/- 83.6 mu g/g extract in LS). The antioxidant capacity was evaluated by DPPH and TAC assays, and the stronger antioxidant activity in ethyl acetate fractions was highlighted. Both species were more active against Gram-positive bacteria than Gram negatives and showed considerable growth inhibitions against tested fungi. Interestingly, selective acetylcholinesterase (AChE) activity was observed with LE and LS. Particularly, the water fraction of LS strongly inhibited AChE (IC50 = 0.199 +/- 0.009 mu g/mL). The ethyl acetate fractions of LE and LS, as well as the n-hexane fraction of LE, exhibited significant antityrosinase activity (IC50 = 245.56 +/- 3.6, 295.18 +/- 10.57 and 148.27 +/- 3.33 mu g/mL, respectively). The ethyl acetate fraction and methanol extract of LS also significantly inhibited pancreatic lipase (IC50 = 83.76 +/- 4.19 and 162.2 +/- 7.29 mu g/mL, respectively). Taken together, these findings warrant further investigations to assess the potential of LE and LS as a bioactive source that can be exploited in pharmaceutical, cosmetics and food industries.en_US
dc.description.sponsorshipAnadolu University Scientific Research Projects Commission [2105S034]; Hacettepe University Scientific Research Projects Coordination Unit [014 D06 301 003-666]en_US
dc.description.sponsorshipThis study was supported by Anadolu University Scientific Research Projects Commission under the grant no: 2105S034 and Hacettepe University Scientific Research Projects Coordination Unit under the grant no: 014 D06 301 003-666.en_US
dc.identifier.doi10.3390/molecules26134040
dc.identifier.issn1420-3049
dc.identifier.issue13en_US
dc.identifier.pmid34279385
dc.identifier.scopus2-s2.0-85110000540
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/molecules26134040
dc.identifier.urihttps://hdl.handle.net/11468/19282
dc.identifier.volume26en_US
dc.identifier.wosWOS:000670978500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLimonium Effusumen_US
dc.subjectLimonium Sinuatumen_US
dc.subjectPlumbaginaceaeen_US
dc.subjectPhenolicsen_US
dc.subjectLc-Msen_US
dc.subjectMsen_US
dc.subjectAntioxidanten_US
dc.subjectAntimicrobialen_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntityrosinaseen_US
dc.subjectPancreatic Lipaseen_US
dc.subjectEnzyme Inhibitionen_US
dc.titleIdentification of Phenolic Compounds by LC-MS/MS and Evaluation of Bioactive Properties of Two Edible Halophytes: Limonium effusum and L. sinuatumen_US
dc.titleIdentification of Phenolic Compounds by LC-MS/MS and Evaluation of Bioactive Properties of Two Edible Halophytes: Limonium effusum and L. sinuatum
dc.typeArticleen_US

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