Central nervous system blastic crisis in chronic myeloid leukemia on imatinib mesylate therapy: a case report

Basit Öğe Kaydı
dc.contributor.authorAltintas, Abdullah
dc.contributor.authorCil, Timucin
dc.contributor.authorKilinc, Ilhan
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorAyyildiz, Orhan
dc.date.accessioned2024-04-24T16:02:18Z
dc.date.available2024-04-24T16:02:18Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractChronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by a reciprocal translocation between chromosomes 9 and 22. Imatinib mesylate is a potent and selective inhibitory of the BCR/ABL tyrosine kinase. Imatinib is a first choice of treatment of chronic phase CML. It has also shown activity in patients with CML in accelerated or blastic phases. However, the penetration of the drug and its active metabolites into the central nervous system (CNS) is poor. Therefore, the CNS is sanctuary site for malignant cells in patients treated with imatinib. Herein, we report a patient with CML in accelerated phase that developed central nervous system disease while on imatinib mesylate therapy.en_US
dc.identifier.doi10.1007/s11060-007-9352-0
dc.identifier.endpage105en_US
dc.identifier.issn0167-594X
dc.identifier.issue1en_US
dc.identifier.pmid17318411
dc.identifier.scopus2-s2.0-34547107099
dc.identifier.scopusqualityQ1
dc.identifier.startpage103en_US
dc.identifier.urihttps://doi.org/10.1007/s11060-007-9352-0
dc.identifier.urihttps://hdl.handle.net/11468/14732
dc.identifier.volume84en_US
dc.identifier.wosWOS:000248006700015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Neuro-Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Myeloid Leukemiaen_US
dc.subjectBlastic Phaseen_US
dc.subjectImatinib Mesylateen_US
dc.subjectMeningeal Leukemiaen_US
dc.titleCentral nervous system blastic crisis in chronic myeloid leukemia on imatinib mesylate therapy: a case reporten_US
dc.titleCentral nervous system blastic crisis in chronic myeloid leukemia on imatinib mesylate therapy: a case report
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu