Alterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit

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dc.contributor.authorSezgi, Cengizhan
dc.contributor.authorTaylan, Mahsuk
dc.contributor.authorKaya, Halide
dc.contributor.authorSen, Hadice Selimoglu
dc.contributor.authorAbakay, Ozlem
dc.contributor.authorDemir, Melike
dc.contributor.authorAbakay, Abdurrrahman
dc.date.accessioned2024-04-24T17:11:26Z
dc.date.available2024-04-24T17:11:26Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroductionThrombocytopenia is associated with increased mortality in intensive care unit (ICU) patients. Mean platelet volume (MPV) reflects platelet function and activation. Elevated MPV is associated with poor outcomes and increased mortality rate in diseases that are commonly encountered in the respiratory ICU. MethodsWe retrospectively enrolled 95 patients who died in the ICU (dead group), 80 patients who improved and were transferred from the ICU (survived group), and 80 healthy individuals as controls. Laboratory parameters including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), albumin, and complete blood count (CBC) were recorded within 24h on admission and transfered from the ICU or died. White blood cell (WBC) count, hemoglobin (Hb), red cell distribution width, MPV, platelet distribution width (PDW), and platelet count (PC) were obtained from the CBC. ResultsAdmission PC and MPV levels were not different in the survived and dead groups. But in the survived group, admission WBC, MPV and PDW levels decreased, while PC increased when compared with admission levels. In the dead group, admission MPV and PDW levels increased, while PC decreased with respect to admission levels. The admission mean PC of the dead group was 182103, which was above the thrombocytopenia limit. The ratio of admission thrombocytopenia was 45.3% in the dead group, which was significantly higher than that of the survived group (13.8%) (P<0.001) ConclusionsIncreasing MPV and decreasing platelet count may alert intensivists to the worse course of disease in patients who had normal platelet counts at ICU admission. The development of thrombocytopenia may also be essential to assessing the outcome of ICU patientsen_US
dc.identifier.doi10.1111/crj.12151
dc.identifier.endpage408en_US
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue4en_US
dc.identifier.pmid24725778
dc.identifier.scopus2-s2.0-84943262364
dc.identifier.scopusqualityQ3
dc.identifier.startpage403en_US
dc.identifier.urihttps://doi.org/10.1111/crj.12151
dc.identifier.urihttps://hdl.handle.net/11468/17515
dc.identifier.volume9en_US
dc.identifier.wosWOS:000362588000004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Respiratory Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectPlatelet Counten_US
dc.subjectRespiratory Intensive Care Uniten_US
dc.subjectThrombocytopeniaen_US
dc.titleAlterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care uniten_US
dc.titleAlterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit
dc.typeArticleen_US

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