Ellagic acid protected the gingival tissue via fibroblast and epidermal growth factors in rats

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dc.contributor.authorTekin, Gulucag Giray
dc.contributor.authorDeveci, Busra
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:18:09Z
dc.date.available2024-04-24T17:18:09Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: To investigate the effect of ellagic acid (EA) in gingival tissues injury in rats. Methods: Twenty rats were categorized into two groups. In burn group, an excisional wound area was created by removing a 4-mm diameter flap from the left molar region in the mucoperiosteal region of the gingiva. In burn + ellagic acid group, 1.2 mg/mL EA was administered as irrigation for one week. Animals was sacrificed under anesthesia at the end of experiment. Malondialdehyde (MDA), myeloperoxidase (MPO) and glutathione (GSH) level were measured. Hematoxylin and eosin, fibroblast growth factor (FGF) and epidermal growth factor (EGF) immunostainings were applied to tissues. Results: MDA, MPO, inflammation and leukocyte infiltration were high in burn group. Degeneration epithelium, edema and inflammatory cell infiltration in connective tissue areas, and dilatation and congestion in blood vessels were observed in burn group. In burn + EA group, the gingival epithelium improved, collagen fiber production increased and organized dermis were observed. After burn injury, FGF and EGF activity was increased in EA treated groups. Conclusion: We suggest that EA have the potential for better healing outcomes in oral wounds. EA seems to have promising therapeutic efficacy to enhance oral wound healing.en_US
dc.identifier.doi10.1590/acb391224
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.pmid38477786
dc.identifier.scopus2-s2.0-85187681281
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/acb391224
dc.identifier.urihttps://hdl.handle.net/11468/18635
dc.identifier.volume39en_US
dc.identifier.wosWOS:001184304800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEllagic Acid.en_US
dc.subjectGingiva.en_US
dc.subjectEpidermal Growth Factoren_US
dc.subjectFibroblast Growth Factorsen_US
dc.subjectAntioxidants. Ratsen_US
dc.titleEllagic acid protected the gingival tissue via fibroblast and epidermal growth factors in ratsen_US
dc.titleEllagic acid protected the gingival tissue via fibroblast and epidermal growth factors in rats
dc.typeArticleen_US

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