Investigation of precore/core mutation of Hepatitis B virus with line probe immune assay method

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dc.authorid0000-0002-8593-224Xen_US
dc.authorid0000-0002-3402-2625en_US
dc.authorid0000-0001-6898-7516en_US
dc.authorid0000-0003-3475-660Xen_US
dc.contributor.authorÖzbek, Erdal
dc.contributor.authorTemiz, Hakan
dc.contributor.authorÖzcan, Nida
dc.contributor.authorÖzekinci, Tuncer
dc.date.accessioned2022-03-22T08:07:15Z
dc.date.available2022-03-22T08:07:15Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000765832800001
dc.description.abstractOBJECTIVE: The expression of hepatitis B e antigen (HBeAg) is reduced or totally inhibited as a result of mutations in the precore/core region of the hepatitis B virus (HBV) genome, but its clinical significance has not been yet fully understood. In this study, we aimed to investigate precore/core mutation in serum samples of patients followed with a chronic hepatitis B infection diagnosis and whose HBeAg was found to be negative on ELISA test. STUDY DESIGN: Among the chronic hepatitis B pa-tients followed in our hospital, serum samples of 111 patients with HBeAg negative were included in the study. In the serums of the patients whose HBV DNA were found positive with real-time PCR assay were investigated ''precore, core" mutations with the INNO-LiPA method. RESULTS: HBV DNA was detected as positive in 93 serum samples. In 42 of those 93 (45.2%) serums, pre- core/core mutations were detected. Isolated precore mu-tation in 12 cases (12.9%), isolated core mutation in 9 cases (9.7%), and both precore and core mutations in 21 cases (22.6%) were found. CONCLUSION: Mutant strains may play an important role in becoming chronic, hepato-carcinogenesis, and in the development of fulminant hepatitis or asymptomatic course. Until valid results are obtained revealing the otherwise, it must be kept in mind that there might be a risk factor of the nucleotide changes in the core re-gion associated with the activation of hepatitis B.en_US
dc.identifier.citationÖzbek, E., Temiz, H., Özcan, N. ve Özekinci, T. (2021). Investigation of precore/core mutation of Hepatitis B virus with line probe immune assay method. Analytical and Quantitave Cytopathology and Histopathology, 43(5), 289-295.en_US
dc.identifier.endpage295en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://hdl.handle.net/11468/9477
dc.identifier.volume43en_US
dc.identifier.wosWoSIDEksik
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorÖzbek, Erdal
dc.institutionauthorTemiz, Hakan
dc.institutionauthorÖzcan, Nida
dc.institutionauthorÖzekinci, Tuncer
dc.language.isoenen_US
dc.publisherSCI Printers & Publication INCen_US
dc.relation.ispartofAnalytical and Quantitave Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBasal core promoteren_US
dc.subjectGenotyping techniquesen_US
dc.subjectHBeAgen_US
dc.subjectHepatitis B chronicen_US
dc.subjectHepatitis B core antigensen_US
dc.subjectHepatitis B e antigensen_US
dc.subjectHepatitis B virusen_US
dc.subjectINNO-LiPAen_US
dc.subjectLiver diseasesen_US
dc.subjectPrecore/core mutationen_US
dc.subjectPromoter regionsen_US
dc.subjectGeneticen_US
dc.titleInvestigation of precore/core mutation of Hepatitis B virus with line probe immune assay methoden_US
dc.titleInvestigation of precore/core mutation of Hepatitis B virus with line probe immune assay method
dc.typeArticleen_US

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