Accelerated hepatitis B vaccination schedule in childhood

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dc.authorid0000-0002-5299-9480en_US
dc.authorid0000-0002-8390-5109en_US
dc.contributor.authorBoşnak, Mehmet
dc.contributor.authorDikici, Bünyamin
dc.contributor.authorBoşnak, Vuslat
dc.contributor.authorHaspolat, Yusuf Kenan
dc.date.accessioned2021-12-01T06:28:40Z
dc.date.available2021-12-01T06:28:40Z
dc.date.issued2002en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: For children travelling to a hepatitis B virus (HBV) endemic area or before a treatment by blood or blood productions, the conventional HBV vaccination schedule takes too long to be completed. There may be problems in the completion of the whole vaccination schedule in developing countries because of particular problems. In these situations an accelerated schedule may be useful for HBV vaccination. Methods: In this study, 40 children were randomly divided into two groups. Groups were vaccinated according to two different schedules; schedule A: one dose at 0, 1, and 6 months and schedule B: one dose at 0, 10, and 21 days (Engerix B, 10 mcg/0.5 ml, GlaxoSmithKline). Follow-up blood samples were obtained at 1, 6 and 12 months after the first vaccine injection. Results: Seroconversion rates were 35 and 80% 1 month after the first vaccine injection, 95 and 80% at 6 months, 95 and 100% at 12 months, in groups A and B respectively. Seroprotection rates were 20 and 65% 1 month after the first vaccine injection, 85 and 70% at 6 months, 95 and 95% at 12 months, in groups A and B respectively. Seroconversion and seroprotection rates was significantly different at day 28 in accelerated vaccination schedule (P < 0.005). Conclusions: In conclusion, an accelerated vaccination course against HBV (three doses at 0, 10, and 21 days) elicited protective levels of anti-HBs antibodies more rapidly than a classic course (three doses at 0, 1, and 6 months) and without a difference in the rate of seroprotection after 1 year. The accelerated 3-week recombinant HBV vaccination schedule should be recommended for HBV prophylaxis when children, such as hurried travellers, who have to have blood and blood productions, or an estimated irregular vaccination, where they have < 1 month to complete the standard HBV vaccination schedule before travelling to HBV endemic areas.en_US
dc.identifier.citationBoşnak, M., Dikici, B., Boşnak, V. ve Haspolat, Y. K. (2002). Accelerated hepatitis B vaccination schedule in childhood. Pediatrics international, 44(6), 663-665.en_US
dc.identifier.doi10.1046/j.1442-200x.2002.01621.x
dc.identifier.endpage665en_US
dc.identifier.issn1442-200X
dc.identifier.issue6en_US
dc.identifier.pmid12421266
dc.identifier.scopus2-s2.0-0036434441
dc.identifier.scopusqualityQ3
dc.identifier.startpage663en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/12421266/
dc.identifier.urihttps://hdl.handle.net/11468/8344
dc.identifier.volume44en_US
dc.identifier.wosWOS:000179043300015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBoşnak, Mehmet
dc.institutionauthorDikici, Bünyamin
dc.institutionauthorBoşnak, Vuslat
dc.institutionauthorHaspolat, Yusuf Kenan
dc.language.isoenen_US
dc.publisherJapan Pediatric Societyen_US
dc.relation.ispartofPediatrics international
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectHepatitis Ben_US
dc.subjectImmunizationen_US
dc.subjectVaccineen_US
dc.titleAccelerated hepatitis B vaccination schedule in childhooden_US
dc.titleAccelerated hepatitis B vaccination schedule in childhood
dc.typeArticleen_US

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