Effect of graft application and nebivolol treatment on tibial bone defect in rats

Basit Öğe Kaydı
dc.authorid0000-0002-9714-4670en_US
dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorGem, Mehmet
dc.contributor.authorŞahin, İlhami
dc.contributor.authorUzel, Kadir
dc.contributor.authorErmiş, Işılay Sezen
dc.contributor.authorDeveci, Engin
dc.date.accessioned2021-11-05T12:49:04Z
dc.date.available2021-11-05T12:49:04Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000708937900010
dc.description.abstractOBJECTIVE: To evaluate the results of the effect of nebivolol on tibial bone defect and graft application in new bone development in the rat. STUDY DESIGN: Thirty Wistar albino rats were divided into 3 groups. In the Control group, tibia bone defect was created without any treatment. In the Defect+ Graft group, allograft treatment was performed by forming a 6 mm tibial bone defect. In the Defect+ Graft+ Nebivolol group, alloplastic bone graft was placed in the calvarial bone defect and then nebivolol (0.34 mg/mL solution/day) treatment was intraperitoneally applied for 28 days. RESULTS: Histopathological examination revealed inflammation in the defect area, congestion in the vessels, degeneration in collagen fibers, and an increase in osteoclast cells. There was an increase in inflammation and blood vessel structure in graft application, and osteoblastic activity matrix formation after reorganization nebivolol application in collagen fibers. Osteonectin expression was positive in the collagen fiber and matrix, starting in the Graft group, in osteoblasts, whereas in the Nebivolol group, osteoblasts increased in osteocytes and new bone formation. CONCLUSION: Nebivolol is thought to have a positive effect on osteoinductive bone growth factors and contribute to the cell-matrix interaction, in addition to the supporting effect of the graft with its antioxidative effect.en_US
dc.identifier.citationGem, M., Şahin, İ., Uzel, K., Ermiş, I.S. ve Deveci, E. (2021). Effect of graft application and nebivolol treatment on tibial bone defect in rats. Analytical and Quantitave Cytopathology and Histopathology, 43(4), 223-228.en_US
dc.identifier.endpage228en_US
dc.identifier.issn0884-6812
dc.identifier.issue4en_US
dc.identifier.startpage223en_US
dc.identifier.urihttps://hdl.handle.net/11468/8143
dc.identifier.volume43en_US
dc.identifier.wosWOS:000708937900010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorErmiş, Işılay Sezen
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherSci Printers & Publ INCen_US
dc.relation.ispartofAnalytical and Quantitave Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllograften_US
dc.subjectBoneen_US
dc.subjectBone regenerationen_US
dc.subjectDisease models, animalen_US
dc.subjectNebivololen_US
dc.subjectOrthopedic proceduresen_US
dc.subjectOsteonectinen_US
dc.subjectRatsen_US
dc.subjectTibiatibial defecten_US
dc.titleEffect of graft application and nebivolol treatment on tibial bone defect in ratsen_US
dc.titleEffect of graft application and nebivolol treatment on tibial bone defect in rats
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Tıp Bilimleri Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu