Effect of graft application and nebivolol treatment on tibial bone defect in rats
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sci Printers & Publ INC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: To evaluate the results of the effect of nebivolol on tibial bone defect and graft application in new bone development in the rat.
STUDY DESIGN: Thirty Wistar albino rats were divided into 3 groups. In the Control group, tibia bone defect was created without any treatment. In the Defect+ Graft group, allograft treatment was performed by forming a 6 mm tibial bone defect. In the Defect+ Graft+ Nebivolol group, alloplastic bone graft was placed in the calvarial bone defect and then nebivolol (0.34 mg/mL solution/day) treatment was intraperitoneally applied for 28 days.
RESULTS: Histopathological examination revealed inflammation in the defect area, congestion in the vessels, degeneration in collagen fibers, and an increase in osteoclast cells. There was an increase in inflammation and blood vessel structure in graft application, and osteoblastic activity matrix formation after reorganization nebivolol application in collagen fibers. Osteonectin expression was positive in the collagen fiber and matrix, starting in the Graft group, in osteoblasts, whereas in the Nebivolol group, osteoblasts increased in osteocytes and new bone formation.
CONCLUSION: Nebivolol is thought to have a positive effect on osteoinductive bone growth factors and contribute to the cell-matrix interaction, in addition to the supporting effect of the graft with its antioxidative effect.
Açıklama
WOS:000708937900010
Anahtar Kelimeler
Allograft, Bone, Bone regeneration, Disease models, animal, Nebivolol, Orthopedic procedures, Osteonectin, Rats, Tibiatibial defect
Kaynak
Analytical and Quantitave Cytopathology and Histopathology
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
43
Sayı
4
Künye
Gem, M., Şahin, İ., Uzel, K., Ermiş, I.S. ve Deveci, E. (2021). Effect of graft application and nebivolol treatment on tibial bone defect in rats. Analytical and Quantitave Cytopathology and Histopathology, 43(4), 223-228.
