The increase of carcinoembryonic antigen (CEA), high-sensitivity C-reactive protein, and neutrophil/lymphocyte ratio in Parkinson's disease

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dc.contributor.authorAkil, Esref
dc.contributor.authorBulut, Aslihan
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorOzdemir, Hasan Huseyin
dc.contributor.authorArslan, Demet
dc.contributor.authorAluclu, Mehmet Ufuk
dc.date.accessioned2024-04-24T16:02:01Z
dc.date.available2024-04-24T16:02:01Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe role of carcinoembryonic antigen (CEA) in Parkinson's disease (PD) has not been previously investigated. The aim of the present study was to evaluate the serum level of carcinoembryonic antigen, high-sensitivity C-reactive protein (hs-CRP), and Neutrophil/lymphocyte ratio (NLR) among patients with Parkinson's disease and to examine the relationship between these inflammatory markers. The cross-sectional design includes 51 patients with Parkinson's disease and 50 age- and sex-matched healthy controls. We investigated the differences in hs-CRP, CEA, and NLR levels between these two groups. CEA was significantly higher in PD patients relative to the control group (mean 2.40 +/- A 1.51 vs. 1.72 +/- A 0.87 (ng/mL), respectively; p = 0.015). Mean NLR was significantly higher in PD patients relative to the control group (mean 3.1 +/- A 1.3 vs. 2.1 +/- A 0.32, respectively; p < 0.001). Serum level of hs-CRP was higher in PD patients than in control group (mean 1.04 +/- A 0.62 and 0.54 +/- A 0.31, respectively; p < 0.01). Correlation analysis revealed significant correlation between hs-CRP, CEA, and Neutrophil/lymphocyte ratio (p < 0.05). This study demonstrates for the first time the association between CEA, hs-CRP, NLR, and PD. We found CEA, hs-CRP, and NLR levels to be significantly higher in the PD patients than in the normal controls.en_US
dc.description.sponsorshipDicle University DUBAPen_US
dc.description.sponsorshipWe are grateful to Dicle University DUBAP for their sponsorship about English editing of this manuscript.en_US
dc.identifier.doi10.1007/s10072-014-1976-1
dc.identifier.endpage428en_US
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue3en_US
dc.identifier.pmid25288159
dc.identifier.scopus2-s2.0-84925482077
dc.identifier.scopusqualityQ1
dc.identifier.startpage423en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-014-1976-1
dc.identifier.urihttps://hdl.handle.net/11468/14572
dc.identifier.volume36en_US
dc.identifier.wosWOS:000350365000011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectCarcinoembryonic Antigenen_US
dc.subjectHigh-Sensitivity C-Reactive Proteinen_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.subjectPeripheral Inflammationen_US
dc.titleThe increase of carcinoembryonic antigen (CEA), high-sensitivity C-reactive protein, and neutrophil/lymphocyte ratio in Parkinson's diseaseen_US
dc.titleThe increase of carcinoembryonic antigen (CEA), high-sensitivity C-reactive protein, and neutrophil/lymphocyte ratio in Parkinson's disease
dc.typeArticleen_US

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