Cholesterol Levels in Patients with Chronic Lymphocytic Leukemia

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dc.contributor.authorYavasoglu, Irfan
dc.contributor.authorSargin, Gokhan
dc.contributor.authorYilmaz, Fergun
dc.contributor.authorAltindag, Sermin
dc.contributor.authorAkgun, Gulsum
dc.contributor.authorTombak, Anil
dc.contributor.authorToka, Bila
dc.date.accessioned2024-04-24T16:15:10Z
dc.date.available2024-04-24T16:15:10Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractLow cholesterol levels may be accompanied by solid tumors or hematological malignancies such as multiple myeloma. Decreased cholesterol levels have been reported in some experimental studies about chronic lymphocytic leukemia (CLL). It may be associated with tumoral cell metabolism. Herein, we examine blood lipid profiles of patients with newly diagnosed CLL (284 male, 276 female, mean age 64 +/- 11 years) as defined by National Cancer Institute criteria. The control group consisted of 71 healthy subjects with mean age 55 +/- 9 years (28 male, 43 females). 60% of patients with Binet A, while 25% were Binet C. Decreased levels of total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) were observed in patients with CLL than control group (p < 0,001). There was no statistical significance between CLL and control group for triglycerides (TG) and very low density lipoprotein (VLDL), also between HDL-C, VLDL, TG and grades. Cholesterol may metabolized by abnormal lymphocytes in CLL patients.en_US
dc.identifier.doi10.1016/j.jnma.2016.11.006
dc.identifier.endpage27en_US
dc.identifier.issn0027-9684
dc.identifier.issn1943-4693
dc.identifier.issue1en_US
dc.identifier.pmid28259211
dc.identifier.scopus2-s2.0-85009292222
dc.identifier.scopusqualityQ1
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1016/j.jnma.2016.11.006
dc.identifier.urihttps://hdl.handle.net/11468/15685
dc.identifier.volume109en_US
dc.identifier.wosWOS:000397053300006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherNatl Med Assocen_US
dc.relation.ispartofJournal of The National Medical Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood Lipid Profilesen_US
dc.subjectCholesterol Levelsen_US
dc.subjectChronic Lymphocytic Leukemiaen_US
dc.titleCholesterol Levels in Patients with Chronic Lymphocytic Leukemiaen_US
dc.titleCholesterol Levels in Patients with Chronic Lymphocytic Leukemia
dc.typeArticleen_US

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