Comparison of ependymomas and medulloblastomas located in the posterior cranial fossa: An anatomical and histopathological study

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dc.contributor.authorYılmaz, Tevfik
dc.contributor.authorÖztürk, Pınar Aydın
dc.contributor.authorBaşar, İbrahim
dc.contributor.authorTuran, Yahya
dc.contributor.authorAslanoğlu, Barış
dc.contributor.authorAydın, Kamuran
dc.contributor.authorİbiloğlu, İbrahim
dc.contributor.authorTuncer, Mehmet Cudi
dc.date.accessioned2022-07-01T12:05:58Z
dc.date.available2022-07-01T12:05:58Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.descriptionWOS:000636050200002
dc.descriptionPMID: 33821469
dc.description.abstractPURPOSE: Posterior fossa tumors (PFTs) include medulloblastomas, atypical teratoid/rhabdoid tumors, pilocytic astrocytomas, ependymomas, and brainstem gliomas. We evaluated patients with surgery at our clinic, comparing epidemiological, clinical, radiological, and pathological characteristics of medulloblastoma and ependymoma to identify factors that might assist preoperative diagnosis, help to develop treatment algorithms, and have prognostic value after surgery. METHODS: Pediatric patients from 0 to 16 and young adults from 16 to 29 years of age with surgery for pathologically confirmed ependymomas or medulloblastomas between January 2014 and January 2020 were eligible. The study included 19 patients, seven with ependymoma (37%) and 12 with medulloblastoma (63.2%). The ependymoma patients were 5.29 +/- 5.85 years of age, the medulloblastoma patients were 11.58 +/- 8.17 years of age, and 16 patients (84%) were children. RESULTS: Fifteen patients (79%) presented with signs of increased intracranial pressure and four (21%) presented with cerebellar findings. MRI found that 74% (14) of the PSTs were located in the midline, including six of the seven ependymomas (86%) and eight of the 12 medulloblastomas (67%). Enhancement was significantly greater in medulloblastomas compared with ependymomas (p = 0.022). In according to pathology results; synaptophysin, NSE, chromogranin and 50% GFAP positivity were observed in medulloblastoma. Ependymomas were S100 (43%) and vimentin (29%) positive. Ependymoma patients were younger than medulloblastoma patients and more were female. Conclusions: There were no significant differences in the clinical findings, but ependymomas were larger and had greater rates of enhancement and spinal metastasis compared with medulloblastomas.en_US
dc.identifier.citationYılmaz, T., Öztürk, P.A., Başar, İ., Turan, Y., Aslanoğlu, B., Aydın, K. ve diğerleri. (2020). Comparison of ependymomas and medulloblastomas located in the posterior cranial fossa: An anatomical and histopathological study. Archives Italiennes de Biologie, 158(3-4), 74-81. http://doi.org/10.12871/000398292020342en_US
dc.identifier.doi10.12871/000398292020342
dc.identifier.endpage81en_US
dc.identifier.issn0003-9829
dc.identifier.issue3-4en_US
dc.identifier.pmid33821469
dc.identifier.scopus2-s2.0-85103996712
dc.identifier.scopusqualityQ4
dc.identifier.startpage74en_US
dc.identifier.urihttps://hdl.handle.net/11468/10087
dc.identifier.volume158en_US
dc.identifier.wosWOS:000636050200002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Tevfik
dc.institutionauthorBaşar, İbrahim
dc.institutionauthorTuran, Yahya
dc.institutionauthorAslanoğlu, Barış
dc.institutionauthorAydın, Kamuran
dc.institutionauthorİbiloğlu, İbrahim
dc.institutionauthorTuncer, Mehmet Cudi
dc.language.isoenen_US
dc.publisherPisa University Pressen_US
dc.relation.ispartofArchives Italiennes de Biologie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPosterior cranial fossa tumorsen_US
dc.subjectEpithelial Membrane Antigen/EMAen_US
dc.subjectKi-67en_US
dc.subjectMRIen_US
dc.titleComparison of ependymomas and medulloblastomas located in the posterior cranial fossa: An anatomical and histopathological studyen_US
dc.titleComparison of ependymomas and medulloblastomas located in the posterior cranial fossa: An anatomical and histopathological study
dc.typeArticleen_US

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