Alteration of serum and cardiac tissue adropin, copeptin, irisin and TRPM2 expressions in DOX treated male rats

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dc.contributor.authorAydin, S.
dc.contributor.authorEren, M. N.
dc.contributor.authorKuloglu, T.
dc.contributor.authorAydin, S.
dc.contributor.authorYilmaz, M.
dc.contributor.authorGul, E.
dc.contributor.authorKalayci, M.
dc.date.accessioned2024-04-24T17:20:30Z
dc.date.available2024-04-24T17:20:30Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractDoxorubicin (DOX) cardiotoxicity is a significant side effect in cancer survivors. DOX and its metabolites alter cardiac gene expression and affect metabolic energy-related peptides. Adropin, copeptin, irisin and TRPM2 are produced locally in the heart and play a role in energy homeostasis. We investigated the fates of adropin, copeptin, irisin and TRPM2 in serum and cardiac tissues of DOX treated rats. Animals were divided into three groups of six: 1) untreated controls, 2) DOX treated and 3) saline treated. The rats were fed a standard diet ad libitum for 14 days then were sacrificed and heart and serum samples were taken. Adropin, copeptin, irisin levels in tissue homogenates and serum were measured using ELISA. Immunoreactivity of heart tissue adropin, copeptin, irisin and TRPM2 also were investigated. The peptides increased in both serum and cardiac tissue homogenates in animals treated with DOX compared to the other groups. DOX increased adropin in endocardial and myocardial cells, but it decreased expression of copeptin. DOX did not affect endocardial irisin and TRPM2 expressions, but myocardial irisin and TRPM2 expressions were increased. Serum adropin, irisin and copeptin were increased in DOX treated rats. Cardiac adropin, copeptin, irisin and TRPM2 are affected by DOX and may play a role in DOX cardiotoxicity.en_US
dc.identifier.doi10.3109/10520295.2014.977949
dc.identifier.endpage205en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid25434395
dc.identifier.scopus2-s2.0-84964252328
dc.identifier.scopusqualityQ2
dc.identifier.startpage197en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2014.977949
dc.identifier.urihttps://hdl.handle.net/11468/19099
dc.identifier.volume90en_US
dc.identifier.wosWOS:000352110200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdropinen_US
dc.subjectCardiac Tissueen_US
dc.subjectCopeptinen_US
dc.subjectDoxorubicinen_US
dc.subjectIrisinen_US
dc.subjectTrpm2en_US
dc.titleAlteration of serum and cardiac tissue adropin, copeptin, irisin and TRPM2 expressions in DOX treated male ratsen_US
dc.titleAlteration of serum and cardiac tissue adropin, copeptin, irisin and TRPM2 expressions in DOX treated male rats
dc.typeArticleen_US

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