Exogenous Amylase Reverses Cerebral Ischemia Induced by Selective Intraarterial Injection of Degradable Starch Microspheres: An Angiographic and Histological Study in a Novel in Vivo Animal Model

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dc.contributor.authorBasar, Ibrahim
dc.contributor.authorHanalioglu, Sahin
dc.contributor.authorBahadir, Sinan
dc.contributor.authorIsikay, Ilkay
dc.contributor.authorAtilla, Pergin
dc.contributor.authorBilginer, Burcak
dc.contributor.authorArat, Anil
dc.date.accessioned2024-04-24T17:24:58Z
dc.date.available2024-04-24T17:24:58Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: To validate a new particulate embolization method using degradable starch microspheres (DSM) and intraarterial exogenous amylase administration, which allow for regulated temporary cerebral arterial embolization without compromising tissue perfusion. MATERIAL and METHODS: Twenty-four male New Zealand rabbits were randomly divided into three groups. All animals underwent routine angiography. The control group received no additional intervention. In the ischemia group, 0.2ml DSM was administered to the animals via the right carotid artery with pulsed, gentle injections to induce ischemia in the cerebral microcirculation. Animals in the reperfusion group received 0.05 ml of exogenous amylase along with DSM administration. Six hours after the procedure, the animals were sacrificed and histopathological analysis was performed. RESULTS: The ischemia group was the most adversely affected group by embolization, with the highest number of pyknotic neurons. The reperfusion group, which received exogenous amylase, had lower pyknotic neurons than the ischemia group. The pyknotic neuron count was similar in some regions between reperfusion and control groups. CONCLUSION: Exogenous amylase can rapidly attenuate cerebral ischemia caused by microembolization with DSM.en_US
dc.identifier.doi10.5137/1019-5149.JTN.36863-21.1
dc.identifier.endpage672en_US
dc.identifier.issn1019-5149
dc.identifier.issue4en_US
dc.identifier.pmid35652177
dc.identifier.scopus2-s2.0-85135063420
dc.identifier.scopusqualityQ3
dc.identifier.startpage667en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.36863-21.1
dc.identifier.urihttps://hdl.handle.net/11468/19892
dc.identifier.volume32en_US
dc.identifier.wosWOS:000838824600018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExogenous Amylaseen_US
dc.subjectCerebral Ischemiaen_US
dc.subjectDegradable Starch Microsphereen_US
dc.subjectAngiographyen_US
dc.subjectRabbit Modelen_US
dc.titleExogenous Amylase Reverses Cerebral Ischemia Induced by Selective Intraarterial Injection of Degradable Starch Microspheres: An Angiographic and Histological Study in a Novel in Vivo Animal Modelen_US
dc.titleExogenous Amylase Reverses Cerebral Ischemia Induced by Selective Intraarterial Injection of Degradable Starch Microspheres: An Angiographic and Histological Study in a Novel in Vivo Animal Model
dc.typeArticleen_US

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