Relationship Between Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels and Inflammatory Bowel Disease Type and Activity

Basit Öğe Kaydı
dc.contributor.authorYesil, Atakan
dc.contributor.authorGonen, Can
dc.contributor.authorSenates, Ebubekir
dc.contributor.authorPaker, Nurcan
dc.contributor.authorGokden, Yasemin
dc.contributor.authorKochan, Koray
dc.contributor.authorErdem, Emrullah Duzgun
dc.date.accessioned2024-04-24T16:02:08Z
dc.date.available2024-04-24T16:02:08Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Aim Neutrophil gelatinase associated lipocalin (NGAL) is a recently identified molecule, which is bacteriostatic, has tissue destructive effects and is proinflammatory with chemoattractant molecule binding properties. Our aim was to investigate the relationship between serum NGAL levels and the type and level of disease activity of IBD. Methods A total of 92 patients [43 with Crohn's disease (CD) and 49 with ulcerative colitis (UC)], and 30 age-and sex-matched healthy controls (HC) were included in this study. Serum NGAL levels were measured using ELISA. Results Serum NGAL levels were elevated in the IBD group [median 171, range (57-312) ng/mL] compared to the HC group [107 (45-234) ng/mL] (p < 0.0001) and were elevated in UC patients [188 (74-312) ng/mL] compared to CD patients [168 (57-279) ng/mL] (p = 0.006). When NGAL levels were further analysed based on localization of the CD and UC, the levels in ulcerative pancolitis [233 (144-312) ng/mL] were significantly higher (p = 0.004) than the left-sided colitis [156 (103-309) ng/mL]. Similarly, NGAL levels were significantly higher in colonic CD [207 (125-249) ng/mL] than ileal CD [114 (78-210) ng/mL], and also in ileocolonic CD [198 (57-279) ng/mL] than ileal CD (p = 0.033). When CD and UC groups were further categorized as active and inactive according to clinical and endoscopic activity indices, serum NGAL concentrations did not differ between inquiescent versus active stages. When a cut-off level of 129 ng/mL was used to distinguish IBD from HC, a sensitivity of 76.1 % and a specificity of 60.9 % was reached. Conclusions The serum NGAL levels in the IBD group was significantly higher than the HC group. Serum NGAL levels were higher in more extensive colonic involvement.en_US
dc.identifier.doi10.1007/s10620-013-2676-z
dc.identifier.endpage2593en_US
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.issue9en_US
dc.identifier.pmid23633156
dc.identifier.scopus2-s2.0-84884211082
dc.identifier.scopusqualityQ1
dc.identifier.startpage2587en_US
dc.identifier.urihttps://doi.org/10.1007/s10620-013-2676-z
dc.identifier.urihttps://hdl.handle.net/11468/14648
dc.identifier.volume58en_US
dc.identifier.wosWOS:000324246300041
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofDigestive Diseases and Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrohn's Diseaseen_US
dc.subjectUlcerative Colitisen_US
dc.subjectNeutrophil Gelatinase Associated Lipocalinen_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.titleRelationship Between Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels and Inflammatory Bowel Disease Type and Activityen_US
dc.titleRelationship Between Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels and Inflammatory Bowel Disease Type and Activity
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu