18f-fluorodeoxyglucose pet/ct can be an alternative method to assessment of insulin resistance

Basit Öğe Kaydı
dc.authorid0000-0002-5323-2257en_US
dc.authorid0000-0002-1814-9773en_US
dc.contributor.authorTuzcu, Şadiye Altun
dc.contributor.authorÇetin, F. A.
dc.contributor.authorPekkolay, Zafer
dc.contributor.authorTuzcu, Alpaslan Kemal
dc.date.accessioned2021-09-13T06:04:25Z
dc.date.available2021-09-13T06:04:25Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Ana Bilim Dalıen_US
dc.description.abstractBackground. Insulin resistance is routinely measured by homeostasis model assessment of insulin resistance (HOMA-IR).Positron emission tomography of 18F-fluorodeoxyglucose combined with computed tomography (18F-FDG PET/CT) is a valuable assessment tool for patients with cancer or staging tumors. 18F-FDG PET/CT imaging can also be utilised to detect the metabolic activity of glucose in the adipose tissue, liver and muscles. The aim of this study was to determine insulin sensitivity in the liver, muscle visceral adipose and subcutaneous adipose tissue separately via18F-FDG PET/CT. Materials and method. Sixty three adult patients who underwent whole body 18F-FDG PET/CT scanning for clinical purposes (diagnosis or staging of cancer) between July and August of 2016 were included in the study. Patients were divided into two groups according to their BMI (Group 1: BMI<25kg/m2, Group 2: BMI>25kg/ m2). HOMA-IR,fasting glucose,insulin, triglycerides, total cholesterol, HDL levels were measured. We calculated SUV as the tissue activity of the ROI (MBq/g)/(injected dose [MBq]/ body weight [g]) on PET images and measured the maximum SUVs (SUVmax) of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT),liver and rectus muscle ROIs (2 cm). SUV corrected by blood glucose level (SUVgluc) was calculated as SUVmax×blood glucose level/100. Student-t test, Chi-square test and Pearson correlation test were used for statistical analysis. Results. Mean glucose,insulin,HOMA-IR levels of the group-2 were statistically higher than of group-1. Muscle SUVmax and liver SUVmax of group-1 were statistically higher than of group-2. Muscle SUVgluc of group-1 was statistically higher than of group-2. HOMA-IR was negatively correlated with both SUVmax(r=-0.340, p=0.01) and muscle SUVmax(r=-0.373, p=0.005) Conclusion. 18F-FDG PET/CT has shown that the muscle tissue maximum FDG uptake was lower in the insulin resistance group. Therefore, 18-FDG PET/CT could be a valuable tool for diagnosing insulin resistance.en_US
dc.identifier.citationTuzcu, Ş. A., Çetin, F. A., Pekkolay, Z. ve Tuzcu, A. K. (2019). 18f-fluorodeoxyglucose pet/ct can be an alternative method to assessment of insulin resistance. Acta Endocrinologica, 15(4), 539-543.en_US
dc.identifier.doi10.4183/aeb.2019.539
dc.identifier.endpage543en_US
dc.identifier.issn1841-0987
dc.identifier.issue4en_US
dc.identifier.pmid32377256
dc.identifier.scopus2-s2.0-85089621184
dc.identifier.scopusqualityQ4
dc.identifier.startpage539en_US
dc.identifier.urihttps://acta-endo.ro/Archive/Abstract?doi=2019.539
dc.identifier.urihttps://hdl.handle.net/11468/7526
dc.identifier.volume15en_US
dc.identifier.wosWOS:000540348500021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTuzcu, Şadiye Altun
dc.institutionauthorF. A., Çetin
dc.institutionauthorPekkolay, Zafer
dc.institutionauthorTuzcu, Alpaslan Kemal
dc.language.isoenen_US
dc.publisherActa Endocrinologica Foundationen_US
dc.relation.ispartofActa Endocrinologica
dc.relation.publicationcategoryRaporen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject18-FDG PET/CTen_US
dc.subjectHOMAen_US
dc.subjectInsulin resistanceen_US
dc.title18f-fluorodeoxyglucose pet/ct can be an alternative method to assessment of insulin resistanceen_US
dc.title18f-fluorodeoxyglucose pet/ct can be an alternative method to assessment of insulin resistance
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
18F-FLUORODEOXYGLUCOSE PET CT CAN BE AN ALTERNATIVE METHOD TO.pdf
Boyut:
457.97 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Dahili Tıp Bilimleri Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu