Relation between coronary artery disease, risk factors and intima-media thickness of carotid artery, arterial distensibility, and stiffness index

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dc.contributor.authorAlan, S
dc.contributor.authorUlgen, MS
dc.contributor.authorOzturk, O
dc.contributor.authorAlan, B
dc.contributor.authorOzdemir, L
dc.contributor.authorToprak, N
dc.date.accessioned2024-04-24T17:14:31Z
dc.date.available2024-04-24T17:14:31Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractAtherosclerosis is a diffuse process that involves vessel structures. In recent years, the relation of noninvasive parameters such as intima-media thickening (IMT), arterial distensibility (AD), and stiffness index (SI) to cardiovascular diseases has been researched. However, we have not found any study that has included all these parameters. The aim of this study is to examine the relation between the presence of coronary artery disease (CAD) and its risk factors to AD, SI, and IMT, which are the noninvasive predictors of atherosclerotic process in the carotid artery. Included in the study were 180 patients who were diagnosed as having CAD by coronary angiography (those with at least; greater than or equal to 30% stenosis in the coronary arteries) and, as a control group, 53 persons who had normal appearing coronary angiographies. IMT, AD, and SI values of all the patients in the study were measured by echo-Doppler imaging (AD formula = 2 x (AoS-AoD)/PP x AoD, SI formula = (SBP/DBP)/([AoS - AoD]/AoD). Significantly increased IMT (0.82 +/-0.1, 0.57 +/-0.1, p<0.05), decreased AD (0.25 +/-0.9, 0.37 +/-0.1, p<0.05), and increased SI (13 +/-4, 8 +/-3, p<0.05) values were detected in the CAD group compared to the control group. A significant correlation was found between IMT and presence of diabetes mellitus (DM), systolic blood pressure, total cholesterol, and presence of plaque in carotids, and age. In the coronary artery disease group there was a significant correlation between AD and age, systolic blood pressure, and HDL cholesterol levels, while there was no significant correlation with plaque development. A significant correlation was also found between stiffness index and systolic blood pressure and age; however, there was no relation between number of involved vessels and IMT, AD, and SI. We found sensitivity, specificity, and positive predictive and negative predictive values for CAD diagnosis to be 70%, 75%, 77%, and 66%, respectively. In CAD cases, according to data in this study, IMT and SI increased while AD decreased, and this was detected by carotid artery Doppler ultrasonography. Therefore, it was concluded that these cheaper, noninvasive, and easily available parameters could be used in early diagnosis of CAD.en_US
dc.identifier.doi10.1177/000331970305400301
dc.identifier.endpage267en_US
dc.identifier.issn0003-3197
dc.identifier.issue3en_US
dc.identifier.pmid12785018
dc.identifier.scopus2-s2.0-0037947519
dc.identifier.scopusqualityQ2
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.1177/000331970305400301
dc.identifier.urihttps://hdl.handle.net/11468/18027
dc.identifier.volume54en_US
dc.identifier.wosWOS:000182920800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWestminster Publ Incen_US
dc.relation.ispartofAngiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleRelation between coronary artery disease, risk factors and intima-media thickness of carotid artery, arterial distensibility, and stiffness indexen_US
dc.titleRelation between coronary artery disease, risk factors and intima-media thickness of carotid artery, arterial distensibility, and stiffness index
dc.typeArticleen_US

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