Evaluation of total oxidative status in adult attention deficit hyperactivity disorder and its diagnostic implications

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dc.contributor.authorSelek, Salih
dc.contributor.authorBulut, Mahmut
dc.contributor.authorOcak, Ali Riza
dc.contributor.authorKalenderoglu, Aysun
dc.contributor.authorSavas, Haluk A.
dc.date.accessioned2024-04-24T16:15:20Z
dc.date.available2024-04-24T16:15:20Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractAdult Attention Deficit Hyperactivity Disorder (A-ADHD) is one of the psychiatric disorders which awareness is growing. The exact causes of A-ADHD are still unknown. In addition to neurochemical and neuroanatomic disorders, genetic and environmental factors are discussed in its etiology. In our study, we aimed to evaluate the oxidative status of A-ADHD patients and investigate whether oxidative metabolites can be used as diagnostic tools or not in A-ADHD. Blood samples were taken from enrolled 50 A-ADHD patients and 31 controls in appropriate way and Total Antioxidative Status (TAS), Total Oxidative Status (TOS), and Oxidative Stress Index (OSI) were studied in Harran University Biochemistry Labs. Results were compared between groups and ROC curve was drawn in order to evaluate diagnostic performances. Patients' TAS, TOS and OSI were significantly higher than controls. There was not a significant difference between comorbid cases and only A-ADHD patients in terms of measured values. A-ADHD can be predicted for TOS over 9.8575 mu mol H2O2 Eqv./L level with 86% positive predictive value and %100 negative predictive value. In A-ADHD, oxidative balance is impaired. High antioxidant levels may be compensatory against the oxidant increase. Oxidative parameters may be used in A-ADHD diagnosis. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpsychires.2011.12.007
dc.identifier.endpage455en_US
dc.identifier.issn0022-3956
dc.identifier.issue4en_US
dc.identifier.pmid22257388
dc.identifier.scopus2-s2.0-84858297572
dc.identifier.scopusqualityQ1
dc.identifier.startpage451en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2011.12.007
dc.identifier.urihttps://hdl.handle.net/11468/15762
dc.identifier.volume46en_US
dc.identifier.wosWOS:000302892900005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal of Psychiatric Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdult Attention Deficit Hyperactivity Disorderen_US
dc.subjectOxidative Stressen_US
dc.subjectTotal Oxidative Statusen_US
dc.subjectTotal Antioxidative Statusen_US
dc.subjectOxidative Stress Indexen_US
dc.subjectDiagnosisen_US
dc.titleEvaluation of total oxidative status in adult attention deficit hyperactivity disorder and its diagnostic implicationsen_US
dc.titleEvaluation of total oxidative status in adult attention deficit hyperactivity disorder and its diagnostic implications
dc.typeArticleen_US

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