Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase in distant liver injury induced by renal ischemia-reperfusion in rats

Basit Öğe Kaydı
dc.contributor.authorHekimoglu, A. Tas
dc.contributor.authorToprak, G.
dc.contributor.authorAkkoc, H.
dc.contributor.authorEvliyaoglu, O.
dc.contributor.authorTas, T.
dc.contributor.authorKelle, I.
dc.contributor.authorColpan, L.
dc.date.accessioned2024-04-24T17:37:51Z
dc.date.available2024-04-24T17:37:51Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND AND AIMS: Renal ischemia followed by reperfusion causes remote liver injury. This research was planned to investigate whether 3-aminobenzamide (3-AB), has any preventive effect against distant liver injury triggered by renal IR. MATERIALS AND METHODS: Twenty four rats were randomly divided into three different groups Each group has 8 rats. The groups were as follows: (1) Sham operated group; (2) Renal ischemia-reperfusion (IR) group; (3) Renal IR+3-AB group. 3-AB (10 mg/ kg) was given intraperitoneally 10 minute before reperfusion. At the end of study, the rats were sacrificed. Their liver tissues and serum samples were collected for measurement of malondialdehyde (MDA) levels, total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON-1) activity and nitric oxide (NO). RESULTS: Renal IR injury significantly increased Oxidative stress index (OSI) and MDA, TOS levels and significantly decreased PON-1 actvity and TAS, NO levels in serum and liver tissue (p < 0.05). Despite that, changes in these biochemical parameters related with IR injury were diminished by 3-AB administration (p < 0.05). CONCLUSIONS: The inhibition of PARP [Poly(ADP-Ribose) Polymerase] by 3-AB showed protective effects against distant liver injury triggered by renal ischemia-reperfusion by the ameliorating effects of 3-AB on oxidative stress.en_US
dc.identifier.endpage38en_US
dc.identifier.issn1128-3602
dc.identifier.issue1en_US
dc.identifier.pmid24452939
dc.identifier.scopus2-s2.0-84896940503
dc.identifier.scopusqualityQ2
dc.identifier.startpage34en_US
dc.identifier.urihttps://hdl.handle.net/11468/21215
dc.identifier.volume18en_US
dc.identifier.wosWOS:000331436700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3-Aminobenzamideen_US
dc.subjectPoly (Adp-Ribose) Polymerase (Parp)en_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectRemote Liver Injuryen_US
dc.subjectOxidative Stressen_US
dc.titleProtective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase in distant liver injury induced by renal ischemia-reperfusion in ratsen_US
dc.titleProtective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase in distant liver injury induced by renal ischemia-reperfusion in rats
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu