The accumulation and histological effects of organometallic fungicides Propineb and Maneb in the kidneys of fetus and female rats during pregnancy

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dc.contributor.authorGuven, K
dc.contributor.authorDeveci, E
dc.contributor.authorAkba, O
dc.contributor.authorOnen, A
dc.contributor.authorde Pomerai, D
dc.date.accessioned2024-04-24T16:18:52Z
dc.date.available2024-04-24T16:18:52Z
dc.date.issued1998
dc.departmentDicle Üniversitesien_US
dc.description.abstractDithiocarbamate propineb and maneb are organometal fungicides, which are widely used for the control of diseases in plants. Female Wistar rats were exposed orally to 200 and 400 ppm propineb and 250 ppm maneb, from the sixth day of gestation up to birth. We found that the body weights of both one-day old litters and their fungicide-treated mothers were lower than those of controls. Histological examination of the kidneys of fetus and fungicide-treated pregnant females showed a variety of histopathological effects. Moreover, the analysis of zinc (Zn) and manganese (Mn) concentrations (using inductively coupled plasma-atomic emission spectrometry) in the kidneys of pregnant females exposed to organometallic fungicides during pregnancy demonstrated that the metal concentrations in the kidney were higher than those of controls. However, the renal metal concentrations were significantly increased in the litters subjected to the fungicides during gestation, indicating that high levels of the trace metals in the organ of fetus may well be due to the fungicides easily passing the placental barrier. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0378-4274(98)00128-3
dc.identifier.endpage98en_US
dc.identifier.issn0378-4274
dc.identifier.issn1879-3169
dc.identifier.issue2en_US
dc.identifier.pmid9817080
dc.identifier.scopus2-s2.0-0032440146
dc.identifier.scopusqualityQ1
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.1016/S0378-4274(98)00128-3
dc.identifier.urihttps://hdl.handle.net/11468/16313
dc.identifier.volume99en_US
dc.identifier.wosWOS:000076829400004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofToxicology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMaternal-Fetal Metal Accumulationen_US
dc.subjectFungicideen_US
dc.subjectPropineben_US
dc.subjectManeben_US
dc.subjectKidneyen_US
dc.subjectHistopathological Effectsen_US
dc.titleThe accumulation and histological effects of organometallic fungicides Propineb and Maneb in the kidneys of fetus and female rats during pregnancyen_US
dc.titleThe accumulation and histological effects of organometallic fungicides Propineb and Maneb in the kidneys of fetus and female rats during pregnancy
dc.typeArticleen_US

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