The effect of periodontal therapy on serum TNF-? and HbA1c levels in type 2 diabetic patients

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dc.contributor.authorDag, A.
dc.contributor.authorFirat, E. T.
dc.contributor.authorArikan, S.
dc.contributor.authorKadiroglu, A. K.
dc.contributor.authorKaplan, A.
dc.date.accessioned2024-04-24T17:11:41Z
dc.date.available2024-04-24T17:11:41Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: To determine the effect of non-surgical periodontal therapy on serum TNF-alpha and HbA1c levels in poorly and well-controlled type 2 diabetic patients. Methods: In total, 45 patients were enrolled in the study; 30 patients with type 2 diabetes mellitus with periodontitis (15 with poorly controlled diabetes, HbA1c >= 7%, group 1A and 15 with well-controlled diabetes, HbA1c < 7%, group 1B) and 15 patients that were systemically healthy with periodontitis (group 2). The plaque index, gingival index, probing depth, clinical attachment loss, gingival bleeding index, HbA1c value, and circulating TNF-alpha concentration were measured at baseline and three months after the non-surgical periodontal therapy. Results: All periodontal parameters and serum TNF-alpha levels were significantly decreased three months after the nonsurgical periodontal therapy compared to the baseline values in all groups. The HbA1c values were significantly decreased only in well-controlled diabetic patients. We found no significant differences in the periodontal parameters or TNF-alpha levels at baseline and after three months between the two groups. Conclusions: Although non-surgical periodontal therapy eliminates local/systemic infection and inflammation via decreases in TNF-alpha, it is insufficient for significantly reducing HbA1c levels without strict glycaemic control in poorly controlled diabetic patients in a short time period.en_US
dc.description.sponsorshipResearching Projects Unit of Dicle University, Turkeyen_US
dc.description.sponsorshipThis study was supported by the Researching Projects Unit of Dicle University, Turkey.en_US
dc.identifier.doi10.1111/j.1834-7819.2008.01083.x
dc.identifier.endpage22en_US
dc.identifier.issn0045-0421
dc.identifier.issn1834-7819
dc.identifier.issue1en_US
dc.identifier.pmid19228128
dc.identifier.scopus2-s2.0-66549098014
dc.identifier.scopusqualityQ2
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.1111/j.1834-7819.2008.01083.x
dc.identifier.urihttps://hdl.handle.net/11468/17673
dc.identifier.volume54en_US
dc.identifier.wosWOS:000263518500005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAustralian Dental Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeriodontitisen_US
dc.subjectPeriodontal Therapyen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectTnf-Alphaen_US
dc.subjectHba1cen_US
dc.titleThe effect of periodontal therapy on serum TNF-? and HbA1c levels in type 2 diabetic patientsen_US
dc.titleThe effect of periodontal therapy on serum TNF-? and HbA1c levels in type 2 diabetic patients
dc.typeArticleen_US

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