Does aspirin use prevent acute coronary syndrome in patients with pneumonia: multicenter prospective randomized trial

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dc.contributor.authorOz, Fahrettin
dc.contributor.authorGul, Sule
dc.contributor.authorKaya, Mehmet G.
dc.contributor.authorYazici, Mehmet
dc.contributor.authorBulut, Ismet
dc.contributor.authorElitok, Ali
dc.contributor.authorErsin, Gunay
dc.date.accessioned2024-04-24T17:08:20Z
dc.date.available2024-04-24T17:08:20Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives The aim of this study was to test the hypothesis that aspirin would reduce the risk for acute coronary syndromes (ACSs) in patients with pneumonia. Backgrounds Pooled data suggest that pneumonia may trigger an ACS as a result of inflammatory reactions and the prothrombotic changes in patients with pneumonia. Hypothetically considering its antiaggregating and anti-inflammatory effects, aspirin might also be beneficial for the primary prevention of ACS in patients with pneumonia. Methods One hundred and eighty-five patients with pneumonia who had more than one risk factor for cardiovascular disease were randomized to an aspirin group (n = 91) or a control group (n = 94). The patients in the aspirin group received 300 mg of aspirin daily for 1 month. ECGs were recorded on admission and 48 h and 30 days after admission to assess silent ischemia. The level of high-sensitivity cardiac troponin T was measured on admission and 48 h after admission. The primary endpoint was the development of ACS within 1 month. The secondary endpoints included cardiovascular death and death from any cause within 1 month. Results The chi(2)-test showed that the rates of ACS at 1 month were 1.1% (n = 1) in the aspirin group and 10.6% (n = 10) in the control group (relative risk, 0.103; 95% confidence interval 0.005-0.746; P = 0.015). Aspirin therapy was associated with a 9% absolute reduction in the risk for ACS. There was no significant decrease in the risk of death from any cause (P = 0.151), but the aspirin group had a decreased risk of cardiovascular death (risk reduction: 0.04, P = 0.044). Conclusion This randomized open-label study shows that acetyl salicylic acid is beneficial in the reduction of ACS and cardiovascular mortality among patients with pneumonia. Coron Artery Dis 24:231-237 (c) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. Coronary Artery Disease 2013, 24:231-237en_US
dc.identifier.doi10.1097/MCA.0b013e32835d7610
dc.identifier.endpage237en_US
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue3en_US
dc.identifier.pmid23283029
dc.identifier.scopus2-s2.0-84876405926
dc.identifier.scopusqualityQ3
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.1097/MCA.0b013e32835d7610
dc.identifier.urihttps://hdl.handle.net/11468/17301
dc.identifier.volume24en_US
dc.identifier.wosWOS:000317395000009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetyl Salicylic Aciden_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectInfection Pneumoniaen_US
dc.subjectPrimary Preventionen_US
dc.titleDoes aspirin use prevent acute coronary syndrome in patients with pneumonia: multicenter prospective randomized trialen_US
dc.titleDoes aspirin use prevent acute coronary syndrome in patients with pneumonia: multicenter prospective randomized trial
dc.typeArticleen_US

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