The Evaluation of Mean Platelet Volume in Hepatitis C Infection

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dc.contributor.authorDemircan, Fatih
dc.contributor.authorKilinc, Faruk
dc.contributor.authorGozel, Nevzat
dc.contributor.authorErkalma Senates, Banu
dc.contributor.authorSenates, Ebubekir
dc.date.accessioned2024-04-24T17:24:32Z
dc.date.available2024-04-24T17:24:32Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Mean platelet volume (MPV) is a simple test that can be detected by routine blood counts and is considered a risk factor for atherothrombosis. In our study, we aimed to compare platelet count and mean platelet volume of patients with diagnosis of hepatitis C with healthy patients groups. Materials and Methods: In this study, blood test results, age and gender of 107 HCV patients and 100 healthy individuals who admitted to our internal medicine polyclinic between January 2010 and August 2013 were evaluated retrospectively. Patient information was obtained from hospital records. Serum platelet counts, MPV, total cholesterol, triglycerides, LDL cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP) levels were recorded. Results: Of the 107 patients diagnosed with HCV, 55 (51.4%) were males and 52 (48.6%) were females and the mean age was 45.0 +/- 11.0 years (range 23-66). In the control group, 51 patients were males and 49 were females, the mean age was 43.9 +/- 12.0 years (range 17-67). The mean ALT and AST levels of the patients with HCV were 58.8 +/- 76.0 IU/L (12-401) and 79.7 +/- 124.6 IU/L (14-670), respectively; in the control group it was 31.6 +/- 12 IU/L (15-82) and 33.1 +/- 10 IU/L (15-78), respectively and the difference between the groups was significant (p<0.001). The mean triglyceride level was significantly higher in the HCV group (205.5 +/- 53.3 mg/dL) than that in the control group (185.5 +/- 34.4 mg/dL) (p<0.001). The mean platelet count was 152.2 +/- 53.8 x 10(3)/mm(3) in patients with HCV infection and it was 190.7 +/- 66.8 x 10(3)/mm(3) in the control group; the difference between the groups was significant (p<0.001). The mean MPV was 9.1 +/- 1.7 fL in HCV group and 7.4 +/- 1.0 fL in the healthy group, and the difference was statistically significant (p<0.001). Conclusion: In conclusion, according to our study; significant elevation in MPV level in patients with HCV infection may be responsible for the effect of the virus that leads to platelet dysfunction. This condition supports the relationship between the existence of HCV infection and the risk of atherothrombosis.en_US
dc.identifier.doi10.4274/Vhd.65365
dc.identifier.endpage14en_US
dc.identifier.issn1307-9441
dc.identifier.issn2147-2939
dc.identifier.issue1en_US
dc.identifier.startpage11en_US
dc.identifier.trdizinid179980
dc.identifier.urihttps://doi.org/10.4274/Vhd.65365
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/179980
dc.identifier.urihttps://hdl.handle.net/11468/19726
dc.identifier.volume20en_US
dc.identifier.wosWOS:000217237300005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofViral Hepatit Dergisi-Viral Hepatitis Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis Cen_US
dc.subjectPlateletsen_US
dc.subjectMean Platelet Volumeen_US
dc.titleThe Evaluation of Mean Platelet Volume in Hepatitis C Infectionen_US
dc.titleThe Evaluation of Mean Platelet Volume in Hepatitis C Infection
dc.typeArticleen_US

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