The Evaluation of Mean Platelet Volume in Hepatitis C Infection
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayincilik
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Mean platelet volume (MPV) is a simple test that can be detected by routine blood counts and is considered a risk factor for atherothrombosis. In our study, we aimed to compare platelet count and mean platelet volume of patients with diagnosis of hepatitis C with healthy patients groups. Materials and Methods: In this study, blood test results, age and gender of 107 HCV patients and 100 healthy individuals who admitted to our internal medicine polyclinic between January 2010 and August 2013 were evaluated retrospectively. Patient information was obtained from hospital records. Serum platelet counts, MPV, total cholesterol, triglycerides, LDL cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP) levels were recorded. Results: Of the 107 patients diagnosed with HCV, 55 (51.4%) were males and 52 (48.6%) were females and the mean age was 45.0 +/- 11.0 years (range 23-66). In the control group, 51 patients were males and 49 were females, the mean age was 43.9 +/- 12.0 years (range 17-67). The mean ALT and AST levels of the patients with HCV were 58.8 +/- 76.0 IU/L (12-401) and 79.7 +/- 124.6 IU/L (14-670), respectively; in the control group it was 31.6 +/- 12 IU/L (15-82) and 33.1 +/- 10 IU/L (15-78), respectively and the difference between the groups was significant (p<0.001). The mean triglyceride level was significantly higher in the HCV group (205.5 +/- 53.3 mg/dL) than that in the control group (185.5 +/- 34.4 mg/dL) (p<0.001). The mean platelet count was 152.2 +/- 53.8 x 10(3)/mm(3) in patients with HCV infection and it was 190.7 +/- 66.8 x 10(3)/mm(3) in the control group; the difference between the groups was significant (p<0.001). The mean MPV was 9.1 +/- 1.7 fL in HCV group and 7.4 +/- 1.0 fL in the healthy group, and the difference was statistically significant (p<0.001). Conclusion: In conclusion, according to our study; significant elevation in MPV level in patients with HCV infection may be responsible for the effect of the virus that leads to platelet dysfunction. This condition supports the relationship between the existence of HCV infection and the risk of atherothrombosis.
Açıklama
Anahtar Kelimeler
Hepatitis C, Platelets, Mean Platelet Volume
Kaynak
Viral Hepatit Dergisi-Viral Hepatitis Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
20
Sayı
1
