Caffeic Acid Phenethyl Ester Protects Kidneys against Acetylsalicylic Acid Toxicity in Rats

Basit Öğe Kaydı
dc.contributor.authorBozkurt, Yasar
dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorTurkcu, Gul
dc.contributor.authorSancaktutar, Ahmet Ali
dc.contributor.authorSoylemez, Haluk
dc.contributor.authorPenbegül, Necmettin
dc.contributor.authorAtar, Murat
dc.date.accessioned2024-04-24T17:20:27Z
dc.date.available2024-04-24T17:20:27Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: The aim of this study was to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced renal damage in rats. Materials and methods: A total of 40 rats were randomly divided into five groups, with eight rats in each group-group 1: control, not receiving any medication; group 2: ASA (50 mg/kg/day); group 3: ASA (50 mg/kg/day) + CAPE (20 mu g/kg/day); group 4: ASA (100 mg/kg/day); and group 5: ASA (100 mg/kg/day) + CAPE (20 mu g/kg/day). ASA and CAPE were given via orogastric gavage for 5 days. The total oxidant status (TOS), total antioxidant capacity (TAC), and paraoxonase-1 (PON-1) activity of the blood samples and kidney tissues were determined. Histopathological examinations of the kidneys were performed using light microscopic methods. Results: The TOS level in the serum of rats and kidney tissues given ASA (groups 2 and 4) significantly increased, but the levels of TAC and PON-1 in these tissues significantly decreased in group 4 when compared with the control rats (p < 0.05). The levels of TAC and PON-1 in the kidney tissues increased and the levels of TOS decreased in the CAPE treatment groups (groups 3 and 5) when compared with the rats in the no CAPE treatment groups (groups 2 and 4). The PON-1, TAC, and TOS values reverted to normal levels in group 5 when compared to group 4 (p < 0.05). These results were supported by histopathological observation. Conclusion: Oxidative stress plays an important role in ASA-induced nephrotoxicity, and CAPE may protect against ASA-induced nephrotoxicity in rats.en_US
dc.identifier.doi10.3109/0886022X.2012.717485
dc.identifier.endpage1155en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue9en_US
dc.identifier.pmid22950656
dc.identifier.scopus2-s2.0-84866386591
dc.identifier.scopusqualityQ2
dc.identifier.startpage1150en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2012.717485
dc.identifier.urihttps://hdl.handle.net/11468/19066
dc.identifier.volume34en_US
dc.identifier.wosWOS:000308956200018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectAcetylsalicylic Aciden_US
dc.subjectKidneyen_US
dc.subjectRatsen_US
dc.titleCaffeic Acid Phenethyl Ester Protects Kidneys against Acetylsalicylic Acid Toxicity in Ratsen_US
dc.titleCaffeic Acid Phenethyl Ester Protects Kidneys against Acetylsalicylic Acid Toxicity in Rats
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu