Brain MRI and MR Spectroscopy Findings in Children with Nutritional Vitamin B12 Deficiency

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dc.contributor.authorEkici, F.
dc.contributor.authorTekbas, G.
dc.contributor.authorHattapoglu, S.
dc.contributor.authorYaramis, A.
dc.contributor.authorOnder, H.
dc.contributor.authorBilici, A.
dc.date.accessioned2024-04-24T15:59:43Z
dc.date.available2024-04-24T15:59:43Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOur aim in this study was to analyze the findings of brain magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) of children with vitamin B-12 deficiency. This study included 14 cases. The findings of brain MRI and MRS in all cases were investigated. Four patients had been followed up and mean follow-up time 71.8 (59-85) day. Eight patients of the cases (57 %) had at least one abnormal MRI finding. The most commonly found MRI findings were thinning of the corpus callosum and brain atrophy, respectively. The mean ratio of NAA/Cr and Cho/Cr were measured in MRS, with values of 1.31 +/- 0.17 and 1.04 +/- 0.27, respectively. In two of three patients with abnormal MRI studies at presentation, subsequent MRI showed improvement while one patient remained unchanged. An increase in the ratios of metabolites were found in one case with control MRS. There was no lactate peak. Brain MRI was abnormal in more than half of the cases of children with vitamin B-12 deficiency. Our radiologic findings similar with literature. There was no identifiable lactate peak. B-12 deficiency could be the cause of the thinning of the corpus callosum and brain atrophy in the children that were given a brain MRI.en_US
dc.identifier.doi10.1007/s00062-014-0351-1
dc.identifier.endpage220en_US
dc.identifier.issn1869-1439
dc.identifier.issn1869-1447
dc.identifier.issue2en_US
dc.identifier.pmid25319952
dc.identifier.scopus2-s2.0-84907888891
dc.identifier.scopusqualityQ2
dc.identifier.startpage215en_US
dc.identifier.urihttps://doi.org/10.1007/s00062-014-0351-1
dc.identifier.urihttps://hdl.handle.net/11468/14226
dc.identifier.volume26en_US
dc.identifier.wosWOS:000379009000012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofClinical Neuroradiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin B-12en_US
dc.subjectDeficiencyen_US
dc.subjectBrain Mrien_US
dc.subjectMr Spectroscopyen_US
dc.titleBrain MRI and MR Spectroscopy Findings in Children with Nutritional Vitamin B12 Deficiencyen_US
dc.titleBrain MRI and MR Spectroscopy Findings in Children with Nutritional Vitamin B12 Deficiency
dc.typeArticleen_US

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