Novel predictor of pulmonary arterial hypertension: Monocyte to HDL cholesterol ratio

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dc.contributor.authorBilik, Mehmet Zihni
dc.contributor.authorOylumlu, Muhammed
dc.contributor.authorOylumlu, Mustafa
dc.contributor.authorAcun, Baris
dc.contributor.authorArik, Baran
dc.contributor.authorArslan, Bayram
dc.contributor.authorAcet, Halit
dc.date.accessioned2024-04-24T17:08:21Z
dc.date.available2024-04-24T17:08:21Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractMonocyte to HDL cholesterol ratio (MHR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) have been proposed as novel systemic inflammatory markers. The aim of this study was to explore the association between MHR, LMR and NLR with pulmonary arterial hypertension (PAH). The study is a single-center, retrospective Cross-sectional study. The study group consisted of 73 patients with PAH and the control group 77 participants without cardiac pathology as determined by echocardiography. On admission, blood sampling to calculate MHR, LMR, NLR, and detailed clinical data were obtained. According to the Pearson test, systolic pulmonary artery pressure (PAP) value Higher MHR, NLR and lower LMR that indicates an enhanced inflammation were significantly increased in patients with PAH when compared with controls. Compared to many other inflammatory markers, these markers are widely available. positively correlated with the MHR and NLR (r:.35, P < .001 and r:.33, P < .001, respectively), but negatively correlated with LMR (r: -.26, P = .001). After multivariate logistic regression analysis, MHR, LMR, and NLR remained as significant predictors of PAH (OR: 2.651, 95% CI: 1.227-5.755, P = .007; OR: 0.647, 95% CI:0.450-0.931, P = .005; OR: 1.350, 95% CI: 1.054-1.650 P = .030, respectively).en_US
dc.identifier.doi10.1097/MD.0000000000029973
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue34en_US
dc.identifier.pmid36042653
dc.identifier.scopus2-s2.0-85136970976
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000029973
dc.identifier.urihttps://hdl.handle.net/11468/17309
dc.identifier.volume101en_US
dc.identifier.wosWOS:000847532100051
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPulmonary Arterial Hypertensionen_US
dc.subjectMonocyte To Hdl Cholesterol Ratioen_US
dc.subjectLymphocyte To Monocyte Ratioen_US
dc.titleNovel predictor of pulmonary arterial hypertension: Monocyte to HDL cholesterol ratioen_US
dc.titleNovel predictor of pulmonary arterial hypertension: Monocyte to HDL cholesterol ratio
dc.typeArticleen_US

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