Markers of disease activity in chronic hepatitis B virus infection

Basit Öğe Kaydı
dc.contributor.authorYalcin, K
dc.contributor.authorDegertekin, H
dc.contributor.authorYildiz, F
dc.contributor.authorCelik, Y
dc.date.accessioned2024-04-24T17:37:38Z
dc.date.available2024-04-24T17:37:38Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Assessment of disease activity is important in the management of chronic hepatitis B virus (HBV) infection. Our objective was to study the correlation between serum HBV DNA levels and HBV e antigen (HBeAg) status, alanine aminotransferase (ALT) levels, histologic activity, age and sex in patients who had chronic HBV, with emphasis on those who were HBeAg negative with high replication but had normal or below-normal liver enzyme levels and mild liver disease. Method: At our university-affiliated tertiary care medical centre in Turkey, we studied prospectively 179 consecutive patients who were long-term hepatitis B surface antigen carriers. These patients were first separated into 2 groups according to HBeAg positivity and then subdivided into 4 groups according to the presence of HBV DNA, HBeAg status and ALT levels. The clinical, virologic and histologic differences in these patients were evaluated with respect to the HBeAg status. Results: Of the 179 patients, 120 (67%) were HBeAg positive and 59 (33%) were HBeAg negative. The mean (and standard deviation) age in the former group was 24.8 (7.60) and in the latter group was 32.2 (11.2) years (p < 0.001). HBeAg-negative patients had significantly more severe liver disease, more male predominance and lower serum HBV DNA levels than HBeAg-positive patients (p < 0.05). HBeAg status had a close correlation with age. There was a significant correlation between age and serum HBV DNA levels but not between HBV DNA levels and disease activity in study groups. We found that some of anti-HBe-positive patients had below-normal ALT levels with minimal or absent histologic changes despite high viral replication. Conclusions: Monitoring of ALT is of value in assessing hepatocellular damage in patients with chronic hepatitis B virus infection. HBeAg-negative patients with elevated ALT levels and some with normal ALT levels should be considered highly infectious in the course of chronic HBV infection.en_US
dc.identifier.endpage34en_US
dc.identifier.issn0147-958X
dc.identifier.issue1en_US
dc.identifier.pmid12659467en_US
dc.identifier.scopus2-s2.0-0038579634en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://hdl.handle.net/11468/21084
dc.identifier.volume26en_US
dc.identifier.wosWOS:000181585600006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCanadian Medical Associationen_US
dc.relation.ispartofClinical and Investigative Medicine-Medecine Clinique Et Experimentaleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlanine Transaminaseen_US
dc.subjectBiological Markersen_US
dc.subjectDna, Viralen_US
dc.subjectHepatitis, Viral, Humanen_US
dc.subjectHepatitis B Antibodiesen_US
dc.subjectHepatitis B, Chronicen_US
dc.subjectHepatitis B E Antigensen_US
dc.subjectHepatitis B Surface Antigensen_US
dc.titleMarkers of disease activity in chronic hepatitis B virus infectionen_US
dc.typeArticleen_US

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