Expression of cadherins and some connective tissue components in cow uterus and placenta during pregnancy

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dc.contributor.authorSagsoz, Hakan
dc.contributor.authorLiman, Narin
dc.contributor.authorAkbalik, M. Erdem
dc.contributor.authorAlan, Emel
dc.contributor.authorSaruhan, Berna Guney
dc.contributor.authorKetani, M. Aydin
dc.contributor.authorErdog, Serkan
dc.date.accessioned2024-04-24T16:18:19Z
dc.date.available2024-04-24T16:18:19Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe implantation and placental development processes are regulated with cell adhesion molecules and remod-eling of the maternal endometrium's extracellular matrices (ECM) and fetal chorion. This study aimed to investigate the distribution and localization of some classical cadherins (E-, N-, and P-cadherins) and extracel-lular matrix components collagen type 5 alpha 1, fibronectin, and laminin in the cow placentomes during pregnancy using immunohistochemical and Western blotting analyses. The study results confirmed the expression of E- and P-cadherins, collagen type V alpha 1 (COLV alpha 1), fibronectin, and laminin in the cow placentomes, but not N-cadherin. Throughout the pregnancy, E-and P-cadherins, COLV alpha 1, and laminin were localized in the luminal and glan-dular epithelium of the inter-caruncular endometrium, caruncular epithelium, and the uninucleate (UNCs) and binucleate trophoblast giant cells (BNCs/TGCs). E- cadherin immunoreactivity in the first pregnancy period was strong in the UNCs while moderate in the BNCs/TGCs. However, it was weak in both trophoblast in the second and third pregnancy periods. In the fetal trophoblasts, P-cadherin and laminin immunostainings were more intense in the BNCs/TGCs than UNCs. The fetal and maternal stromal cells were also positive for P-cadherin, COLV alpha 1, fibronectin, and laminin. The immunostaining intensity of COLV alpha 1 and fibronectin in the stromal extracellular matrix of the placentomes decreased as the pregnancy progressed. The endothelia of fetal and maternal vessels were positive for all proteins. The presence and distinct localization of cadherins and ECM proteins in the cow placentome components support the role of these molecules in regulating placental cell growth, migration, and matrix production during pregnancy.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK ARDEB 1002, 116O797]en_US
dc.description.sponsorshipFunding This work was supported by the the Scientific and Technological Research Council of Turkey (TUBITAK ARDEB 1002 Grant No. 116O797) .en_US
dc.identifier.doi10.1016/j.rvsc.2022.07.006
dc.identifier.endpage79en_US
dc.identifier.issn0034-5288
dc.identifier.issn1532-2661
dc.identifier.pmid35870371
dc.identifier.scopus2-s2.0-85134826246
dc.identifier.scopusqualityQ1
dc.identifier.startpage64en_US
dc.identifier.urihttps://doi.org/10.1016/j.rvsc.2022.07.006
dc.identifier.urihttps://hdl.handle.net/11468/15997
dc.identifier.volume151en_US
dc.identifier.wosWOS:000843032800006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofResearch in Veterinary Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBovineen_US
dc.subjectCollagenen_US
dc.subjectLamininen_US
dc.subjectN-Cadherinen_US
dc.subjectPlacentaen_US
dc.subjectUterusen_US
dc.titleExpression of cadherins and some connective tissue components in cow uterus and placenta during pregnancyen_US
dc.titleExpression of cadherins and some connective tissue components in cow uterus and placenta during pregnancy
dc.typeArticleen_US

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